ArticleWorld journal of gastroenterology1998
In vitro production of TNF-alpha,IL-6 and sIL-2R in Chinese patients with ulcerative colitis.
Article in World journal of gastroenterology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Animal models of inflammatory bowel disease: a review.Inflammopharmacology · 2014Review
- Expression and significance of nuclear factor kappaB p65 in colon tissues of rats with TNBS-induced colitis.World journal of gastroenterology · 2005Article
- Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis.World journal of gastroenterology · 2004Article
- Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats.World journal of gastroenterology · 2003Article
- An analysis of 10218 ulcerative colitis cases in China.World journal of gastroenterology · 2002Review
- Effect of cholecystokinin on cytokines during endotoxic shock in rats.World journal of gastroenterology · 2001Article
- A new chronic ulcerative colitis model produced by combined methods in rats.World journal of gastroenterology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and soluble interleukin 2 receptor (sIL-2r) from peripheral blood mononuclear cells (PBMC) in 25 Chinese patients with ulcerative colitis and 20 healthy controls.
methodsPBMC were isolated by density gradient centrifugation of heparinized blood and cultures for 24 or 48 hours by stimulation with LPS or PHA. TNF-alphaand sIL-2r were measured by ELISA method and IL-6 measured by biossay.
resultsTNF-alphaproduction stimulated by LPS and sIL-2r production by PHA in ulcerative colitis were significantly lower than in healthy controls (TNF-alpha509(46-7244)ng/L vs 1995(117-18 950)ng/L, P < 0.05; sIL-2r 320U/mlplus minus 165U/ml vs 451U/mlplus minus 247U/ml, P < 0.05).Spontaneous TNF-alphaand sIL-2r production were not significantly different between ulcerative colitis and controls (TNF-alpha304(46-7044)ng/L vs 215(46-4009)ng/L,P > 0.05; sIL-2r 264U/mlplus minus 115U/ml vs 236U/mlplus minus139U/ml, P>0.05). IL-6 production by spontaneous release from PBMC in ulcerative colitis group was 109U/mlplus minus 94U/ml vs 44U/mlplus minus 39U/ml for those in healthy controls, P < 0.01. IL-6 stimulated by LPS in ulcerative colitis group was (261U/ml plus minus 80U/ml) higher than in healthy controls (102U/mlplus minus 54U/ml, P < 0.01). No correlation of TNF-alpha, IL-6, sIL-2r production was found to disease activity, disease location and medication.
conclusionCytokine production from PBMC was also disturbed in Chinese patients with ulcerative colitis.
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Registered trials
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