ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cultured rat hippocampal neural progenitors generate spontaneously active neural networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis.Neurochemical research · 2017Review
- High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.Scientific reports · 2017Article
- Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation.The Journal of biological chemistry · 2016Article
- The synthetic NCAM mimetic peptide FGL mobilizes neural stem cells in vitro and in vivo.Stem cell reviews and reports · 2014Article
- Downregulation of transketolase activity is related to inhibition of hippocampal progenitor cell proliferation induced by thiamine deficiency.BioMed research international · 2014Article
- Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons.PloS one · 2013Article
- Differential regulation of proliferation and neuronal differentiation in adult rat spinal cord neural stem/progenitors by ERK1/2, Akt, and PLCγ.Frontiers in molecular neuroscience · 2013Article
- A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates.Mathematical biosciences · 2012Article
- Article
- Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease.Experimental neurology · 2008Article
- Pharmacology of cell adhesion molecules of the nervous system.Current neuropharmacology · 2007Article
- Short- and long-term memory are differentialy modulated by hippocampal nerve growth factor and fibroblast growth factor.Neurochemical research · 2005Article
- Regulation of the hyperpolarization-activated cationic current Ih in mouse hippocampal pyramidal neurones by vitronectin, a component of extracellular matrix.The Journal of physiology · 2004Article
- Gene-environment interplay in neurogenesis and neurodegeneration.Neurotoxicity research · 2004Review
- Regulation of an inactivating potassium current (IA) by the extracellular matrix protein vitronectin in embryonic mouse hippocampal neurones.The Journal of physiology · 2003Article
- Efficient marking of neural stem cell-derived neurons with a modified murine embryonic stem cell virus, MESV2.Gene therapy · 2002Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We previously demonstrated that the neural cell adhesion molecule (N-CAM) inhibited the proliferation of cultured rat hippocampal progenitor cells and increased the number of neurons generated. We demonstrate here that the continued presence of fibroblast growth factor 2 along with N-CAM or brain-derived neurotrophic factor over 12 days of culture greatly increased the number of both progenitors and neurons. These progenitor-derived neurons expressed neurotransmitters, neurotransmitter receptors, and synaptic proteins in vitro consistent with those expressed in the mature hippocampus. Progenitor cells cultured on microelectrode plates formed elaborate neural networks that exhibited spontaneously generated action potentials after 21 days. This activity was observed only in cultures grown in the presence of fibroblast growth factor 2 and either N-CAM or brain-derived neurotrophic factor. Analysis of neuronal activity after various pharmacological treatments indicated that the networks formed functional GABAergic and glutamatergic synapses. We conclude that mitogenic growth factors can synergize with N-CAM or neurotrophins to generate spontaneously active neural networks from neural progenitors.
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