ArticleEMBO reports2002
p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function.Biomolecules · 2021Article
- Targeting intrinsically disordered proteins involved in cancer.Cellular and molecular life sciences : CMLS · 2020Review
- Review
- Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.The Journal of clinical investigation · 2019Article
- Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.Scientific reports · 2018Article
- Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.PloS one · 2016Article
- Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.Journal of cellular physiology · 2015Article
- Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.Scientific reports · 2015Article
- Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence.Cell death and differentiation · 2014Article
- Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.Oncogene · 2014Article
- Expression and roles of As-NUPR1 protein from Artemia sinica during embryo development and in response to salinity stress.Molecular biology reports · 2014Article
- Biotic acts of antibiotics.Frontiers in microbiology · 2013Article
- RAF265 inhibits the growth of advanced human melanoma tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Expression and roles of NUPR1 in cholangiocarcinoma cells.Anatomy & cell biology · 2012Article
- Article
- Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.Molecular biology of the cell · 2010Article
- Stress-inducible protein p8 is involved in several physiological and pathological processes.The Journal of biological chemistry · 2010Review
- The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.Journal of cell science · 2009Article
- A tumor suppressor function for caspase-2.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts.Blood · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p8 protein is involved in the cellular stress response of many tissues. Because p8 is overexpressed in many cancers, we investigated whether its expression was required for tumour development. Mouse embryo fibroblasts (MEFs) from p8+/+ and p8-/- animals were transformed with the pBabe-rasV12/E1A retroviral vector, which expresses both the rasV12 mutated protein and the E1A oncogene. As expected, transformed p8+/+ MEFs could form colonies in soft agar. However, transformed p8-/- MEFs could not. In addition, subcutaneous or intraperitoneal injections of transformed p8+/+ MEFs always led to tumour formation in nude mice, but, again, no tumour was observed with transformed p8-/- MEFs. However, restoring p8 expression in transformed p8-/- MEFs before injection led to tumour formation. In the tumours, p8 expression was induced during tumour development. It was concluded that p8 expression in transformed MEFs is necessary for tumour formation, suggesting that the stress-response mechanisms governed by p8 are required for tumour establishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.