ReviewImmunologic research2001
Sepsis-induced immunosuppression: from bad to worse.
Review in Immunologic research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 133 citations in OpenAlex.
- An Exceptional Case of a Supra-tentorial Streptococcus Salivarius Brain Abscess-A Case Report.Clinical medicine insights. Case reports · 2025Article
- Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study.Frontiers in medicine · 2024Article
- During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant.Clinical reviews in allergy & immunology · 2023Review
- Interrogating the sepsis host immune response using cytomics.Critical care (London, England) · 2023Review
- The prognostic impact of rheumatoid arthritis in sepsis: a population-based analysis.Acute and critical care · 2022Article
- Association of multiple sclerosis with mortality in sepsis: a population-level analysis.Journal of intensive care · 2022Article
- Impact of history of mental disorders on short-term mortality among hospitalized patients with sepsis: A population-based cohort study.PloS one · 2022Article
- Sepsis: Evidence-based pathogenesis and treatment.World journal of critical care medicine · 2021Review
- Proteomic Pathway Analysis of Monocyte-Derived Exosomes during Surgical Sepsis Identifies Immunoregulatory Functions.Surgical infections · 2020Article
- Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway.Frontiers in immunology · 2020Article
- The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study.Critical care (London, England) · 2019Article
- Pediatric Intensive Care: Immunomodulation With Activated Protein CFrontiers in pediatrics · 2019Article
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis.PloS one · 2019Article
- Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture.Pharmaceutical biology · 2018Article
- Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis.Annals of intensive care · 2018Article
- Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree.PloS one · 2018Article
- Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-α and TGF-β1) in murine model.Inflammopharmacology · 2017Article
- Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients.PloS one · 2017Observational
- Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture.Intensive care medicine experimental · 2016Article
- Sepsis in cirrhosis: emerging concepts in pathogenesis, diagnosis and management.Hepatology international · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The sepsis syndrome is characterized by the acute release of a variety of inflammatory mediators, which often result in detrimental effects to the host. The release of these mediators is regulated and counterbalanced by the coordinated expression of antiinflammatory molecules. It is the balance between the expression of pro- and antiinflammatory mediators that often determines the magnitude of early tissue injury and subsequent risk of infectious complications. As our understanding of the pathophysiology of sepsis continues to evolve, we have gained a greater appreciation for the effects that sepsis and similar states of overwhelming stress have on host antimicrobial immunity. A number of functional defects in leukocytes isolated from sepsis patients have been characterized. These defects include diminished expression of important cell surface antigens, dysregulated cytokine production, alterations in antigen-presenting ability, and accelerated apoptosis. Impaired leukocyte function has important clinical ramifications, as high mortality rates have been observed in patients displaying evidence of sepsis-induced immune deactivation. In this article, we review the current literature supporting evidence of dysregulation of host immunity occurring during sepsis syndrome, characterize the underlying pathophysiology, and describe novel therapeutic interventions directed at augmenting host immunity during sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.