ArticleThe Journal of general physiology2002
Two temporal phases of light adaptation in retinal rods.
Article in The Journal of general physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
- Adaptation memory in photoreceptors: different mechanisms in rods and cones.Frontiers in molecular neuroscience · 2023Article
- Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.Frontiers in molecular neuroscience · 2022Article
- Photoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases.Advances in experimental medicine and biology · 2022Review
- Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones.Pflugers Archiv : European journal of physiology · 2021Review
- Functional optical coherence tomography enablesBiomedical optics express · 2020Article
- Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes.PLoS computational biology · 2018Article
- Role of recoverin in rod photoreceptor light adaptation.The Journal of physiology · 2018Article
- Light adaptation and the evolution of vertebrate photoreceptors.The Journal of physiology · 2017Article
- Regulation of Neuronal Oxygen Responses in C. elegans Is Mediated through Interactions between Globin 5 and the H-NOX Domains of Soluble Guanylate Cyclases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Deep Learning Models of the Retinal Response to Natural Scenes.Advances in neural information processing systems · 2016Article
- Timing is everything: GTPase regulation in phototransduction.Investigative ophthalmology & visual science · 2013Review
- Article
- Photoreceptor signaling: supporting vision across a wide range of light intensities.The Journal of biological chemistry · 2012Review
- Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase.Molecular neurobiology · 2011Review
- Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.The Journal of biological chemistry · 2011Article
- Channel modulation and the mechanism of light adaptation in mouse rods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Kinetics of turn-offs of frog rod phototransduction cascade.The Journal of general physiology · 2008Article
- Light adaptation in salamander L-cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
Vertebrate rod photoreceptors adjust their sensitivity as they adapt during exposure to steady light. Light adaptation prevents the rod from saturating and significantly extends its dynamic range. We examined the time course of the onset of light adaptation in bullfrog rods and compared it with the projected onset of feedback reactions thought to underlie light adaptation on the molecular level. We found that adaptation developed in two distinct temporal phases: (1) a fast phase that operated within seconds after the onset of illumination, which is consistent with most previous reports of a 1-2-s time constant for the onset of adaptation; and (2) a slow phase that engaged over tens of seconds of continuous illumination. The fast phase desensitized the rods as much as 80-fold, and was observed at every light intensity tested. The slow phase was observed only at light intensities that suppressed more than half of the dark current. It provided an additional sensitivity loss of up to 40-fold before the rod saturated. Thus, rods achieved a total degree of adaptation of approximately 3,000-fold. Although the fast adaptation is likely to originate from the well characterized Ca(2+)-dependent feedback mechanisms regulating the activities of several phototransduction cascade components, the molecular mechanism underlying slow adaptation is unclear. We tested the hypothesis that the slow adaptation phase is mediated by cGMP dissociation from noncatalytic binding sites on the cGMP phosphodiesterase, which has been shown to reduce the lifetime of activated phosphodiesterase in vitro. Although cGMP dissociated from the noncatalytic binding sites in intact rods with kinetics approximating that for the slow adaptation phase, this hypothesis was ruled out because the intensity of light required for cGMP dissociation far exceeded that required to evoke the slow phase. Other possible mechanisms are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.