ArticleThe Journal of experimental biology2001
Patch-clamp analysis of voltage-activated and chemically activated currents in the vomeronasal organ of Sternotherus odoratus (stinkpot/musk turtle).
Article in The Journal of experimental biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Histochemical and ultrastructural analyses of the lubrication systems in the olfactory organs of soft-shelled turtle.The Journal of veterinary medical science · 2016Article
- A lifetime of neurogenesis in the olfactory system.Frontiers in neuroscience · 2014Review
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Social behavior and pheromonal communication in reptiles.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Review
- The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.BMC neuroscience · 2010Article
- Vomeronasal sensory neurons from Sternotherus odoratus (stinkpot/musk turtle) respond to chemosignals via the phospholipase C system.The Journal of experimental biology · 2006Article
- Heterogeneity of voltage- and chemosignal-activated response profiles in vomeronasal sensory neurons.Journal of neurophysiology · 2005Article
- Voltage-activated current properties of male and female mouse vomeronasal sensory neurons: sexually dichotomous?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2004Article
- Functional specialization of male and female vocal motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Patch-clamp analysis of voltage-activated and chemically activated currents in the vomeronasal organ of Sternotherus odoratus (stinkpot/musk turtle).The Journal of experimental biology · 2001Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The electrophysiological basis of chemical communication in the specialized olfactory division of the vomeronasal (VN) organ is poorly understood. In total, 198 patch-clamp recordings were made from 42 animals (Sternotherus odoratus, the stinkpot/musk turtle) to study the electrically and chemically activated properties of VN neurons. The introduction of tetramethylrhodamine-conjugated dextran into the VN orifice permitted good visualization of the vomeronasal neural epithelium prior to dissociating it into single neurons. Basic electrical properties of the neurons were measured (resting potential, -54.5 +/- 2.7 mV, N=11; input resistance, 6.7 +/- 1.4 G Omega, N=25; capacitance, 4.2 +/- 0.3 pF, N=22; means +/- S.E.M.). The voltage-gated K(+) current inactivation rate was significantly slower in VN neurons from males than in those from females, and K(+) currents in males were less sensitive (greater K(i)) to tetraethylammonium. Vomeronasal neurons were held at a holding potential of -60 mV and tested for their response to five natural chemicals, female urine, male urine, female musk, male musk and catfish extract. Of the 90 VN neurons tested, 33 (34 %) responded to at least one of the five compounds. The peak amplitude of chemically evoked currents ranged from 4 to 180 pA, with two-thirds of responses less than 25 pA. Urine-evoked currents were of either polarity, whereas musk and catfish extract always elicited only inward currents. Urine applied to neurons harvested from female animals evoked currents that were 2-3 times larger than those elicited from male neurons. Musk-evoked inward currents were three times the magnitude of urine- or catfish-extract-evoked inward currents. The calculated breadth of responsiveness for neurons presented with this array of five chemicals indicated that the mean response spectrum of the VN neurons is narrow (H metric 0.11). This patch-clamp study indicates that VN neurons exhibit sexual dimorphism in function and specificity in response to complex natural chemicals.iol
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