ArticleBritish journal of pharmacology2002
Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).British journal of clinical pharmacology · 2010Trial
- Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea: A cross-sectional case-control study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Observational
- IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.Science immunology · 2023Article
- Clinical characteristics of combined rosacea and migraine.Frontiers in medicine · 2022Article
- Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP ActionFrontiers in pharmacology · 2022Article
- Peri-arterial Autonomic Innervation of the Human Ear.Scientific reports · 2018Article
- TRPV1-Like Immunoreactivity in the Human Locus K, a Distinct Subregion of the Cuneate Nucleus.Cells · 2018Article
- TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO.British journal of pharmacology · 2016Article
- Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.Arthritis research & therapy · 2016Article
- Placental ischemia increases seizure susceptibility and cerebrospinal fluid cytokines.Physiological reports · 2015Article
- New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review.Channels (Austin, Tex.) · 2015Review
- Calcitonin gene-related peptide: physiology and pathophysiology.Physiological reviews · 2014Review
- Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo.The Journal of pharmacology and experimental therapeutics · 2011Article
- A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.British journal of pharmacology · 2010Article
- The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa.Marine drugs · 2009Article
- A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Re-sensitization of neuropeptide receptors: should we stop the recycling?British journal of pharmacology · 2009Article
- Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin.Journal of molecular neuroscience : MN · 2008Article
- The assessment of vasoactive properties of CGRP and adrenomedullin in the microvasculature: a study using in vivo and in vitro assays in the mouse.Journal of molecular neuroscience : MN · 2004Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The aims of this study were to develop a technique to measure blood flow in the mouse ear and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK(1) receptor knockout mice (-/-). Blood flow was assessed by laser Doppler flowmetry and oedema formation by (125)I-albumin accumulation. Capsaicin induced significant increases in blood flow (0.2 - 200 microg in 20 microl) and oedema (2 - 200 microg in 20 microl). The oedema response was absent in NK(1)-/- mice and NK(1)+/+mice treated with the selective NK(1) receptor antagonist SR140333 (480 nmol kg(-1)) as expected. Furthermore, the capsaicin-evoked increase in blood flow was significantly potentiated in the knockout mice (203% of wild-type response, P<0.05) and wild-type mice treated with SR140333 (201%, P<0.05). The CGRP receptor antagonist CGRP(8 - 37) (400 nmol kg(-1)) had no effect on capsaicin-induced blood flow in NK(1)+/+mice but abolished the increased blood flow to capsaicin in NK(1)-/-, and NK(1)+/+wild-type mice pre-treated with SR140333. The results indicate that neurogenic vasodilatation can be measured in the mouse ear. The capsaicin-induced increased blood flow involves activation of, and possible interactions between, both NK(1) and CGRP(1) receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.