ArticleAmerican journal of human genetics2002
Extensive linkage disequilibrium in small human populations in Eurasia.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genomic evidence for low genetic diversity but purging of strong deleterious variants in snow leopards.Genome biology · 2025Article
- Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.BMC genomics · 2022Article
- How population growth affects linkage disequilibrium.Genetics · 2014Article
- Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians.American journal of human genetics · 2012Article
- What is known about the health and living conditions of the indigenous people of northern Scandinavia, the Sami?Global health action · 2011Review
- A genome-wide association study for age-related hearing impairment in the Saami.European journal of human genetics : EJHG · 2010Article
- Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami.European journal of human genetics : EJHG · 2010Article
- Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD.BMC genomics · 2009Article
- The value of some Corsican sub-populations for genetic association studies.BMC medical genetics · 2008Article
- Article
- Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe.PloS one · 2008Article
- Forensic efficiency of microsatellites and single nucleotide polymorphisms on the X chromosome.International journal of legal medicine · 2007Article
- Evaluation of the SNP tagging approach in an independent population sample--array-based SNP discovery in Sami.Human genetics · 2007Article
- Investigating the effects of prehistoric migrations in Siberia: genetic variation and the origins of Yakuts.Human genetics · 2006Article
- Lifestyle, genetics, and disease in Sami.Croatian medical journal · 2006Review
- Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes.Journal of medical genetics · 2006Article
- Geography is a better determinant of human genetic differentiation than ethnicity.Human genetics · 2005Article
- Increased level of linkage disequilibrium in rural compared with urban communities: a factor to consider in association-study design.American journal of human genetics · 2005Article
- X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations.European journal of human genetics : EJHG · 2005Article
- Evaluation of microsatellite markers in association studies: a search for an immune-related susceptibility gene in sarcoidosis.Immunogenetics · 2005Article
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8 authors.
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Abstract
The extent of linkage disequilibrium (LD) was studied in two small food-gathering populations-Evenki and Saami-and two larger food-producing populations-Finns and Swedes-in northern Eurasia. In total, 50 single-nucleotide polymorphisms (SNPs) from five genes were genotyped using real-time pyrophosphate DNA sequencing, whereas 14 microsatellites were genotyped in two X-chromosomal regions. In addition, hypervariable region I of the mtDNA was sequenced to shed light on the demographic history of the populations. The SNP data, as well as the microsatellite data, reveal extensive levels of LD in Evenki and Saami when compared to Finns and Swedes. mtDNA-sequence variation is compatible with constant population size over time in Evenki and Saami but indicates population expansion in Finns and Swedes. Furthermore, the similarity between Finns and Swedes in SNP allele- and haplotype-frequency distributions indicate that these two populations may share a recent common origin. These findings suggest that populations such as the Evenki and the Saami, rather than the Finns, may be particularly suited for the initial coarse mapping of common complex diseases.
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