ArticleNucleic acids research2001
Two thyroid hormone-mediated gene expression patterns in vivo identified by cDNA expression arrays in rat.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways.JCI insight · 2026Article
- NRF1 and NRF2 Expression in Preeclamptic Placentas: A Comparative Observational Study.Life (Basel, Switzerland) · 2026Article
- Hypothyroidism/subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease: advances in mechanism and treatment.Lipids in health and disease · 2025Review
- Breast cancer cells utilize T3 to trigger proliferation through cellular CaCell communication and signaling : CCS · 2024Article
- Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling.Thyroid : official journal of the American Thyroid Association · 2022Article
- Review
- Role of irisin in Chinese patients with hypothyroidism: an interventional study.The Journal of international medical research · 2019Article
- Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows.The Journal of endocrinology · 2017Article
- Exogenous thyroxine improves glucose intolerance in insulin-resistant rats.The Journal of endocrinology · 2017Article
- Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.BMC medicine · 2017Article
- Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRClinical epigenetics · 2017Article
- Regulation of skeletal muscle mitochondrial activity by thyroid hormones: focus on the "old" triiodothyronine and the "emerging" 3,5-diiodothyronine.Frontiers in physiology · 2015Review
- Hepatoprotective effect of satureja khuzestanica essential oil and vitamin e in experimental hyperthyroid rats: evidence for role of antioxidant effect.Iranian journal of medical sciences · 2014Article
- FoxO6 and PGC-1α form a regulatory loop in myogenic cells.Bioscience reports · 2013Article
- Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.The Journal of biological chemistry · 2013Article
- The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases.Journal of diabetes research · 2013Article
- SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions.PloS one · 2013Article
- PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta).The Journal of biological chemistry · 2011Article
- Proteomic characterization of early changes induced by triiodothyronine in rat liver.Journal of proteome research · 2011Article
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3 authors.
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Abstract
Thyroid hormone (T3) is essential for normal development, differentiation and metabolic balance. Only a limited number of T3-target genes have been identified so far and their complex regulation pattern is poorly understood. We performed cDNA expression array hybridisation to identify T3-regulated genes and to investigate their expression pattern after various time points in vivo. Radioactively labelled cDNA was prepared from hepatic RNA of hypothyroid and hyperthyroid rats 6, 24 and 48 h after the administration of T3. Labelled cDNA probes were hybridised to rat Atlas Arrays. Twenty-three of 588 genes were shown to be differentially regulated, 18 of which were previously not known to be regulated by T3. The expression of 19 genes was verified by independent northern blot hybridisation. Two different expression time courses of T3 expression were observed. In a first expression profile ('early' expression) the transcription level of the target genes rises within 6 h, drops by 24 h and increases again within 48 h after the administration of T3. In a second expression profile ('late' expression) the mRNA level rose in the first 6 h and rose further by 48 h, indicating an additional regulation mechanism. Nuclear respiratory factor (NRF)-1 and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1), but not NRF-2, were up-regulated within 6 h after T3 administration, suggesting NRF-1 and/or PGC-1 as key regulators for mediating the 'late' expression pattern.
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