ArticleNucleic acids research2001
Distribution of substitution rates and location of insertion sites in the tertiary structure of ribosomal RNA.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
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- Molecular Apomorphies in the Secondary and Tertiary Structures of Length-Variable Regions (LVRs) of 18S rRNA Shed Light on the Systematic Position of the Family Thaumastellidae (Hemiptera: Heteroptera: Pentatomoidea).International journal of molecular sciences · 2023Article
- Review
- Varying strength of selection contributes to the intragenomic diversity of rRNA genes.Nature communications · 2022Article
- Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies.Microbiome · 2022Article
- Insights into Microsporidia Evolution from Early Diverging Microsporidia.Experientia supplementum (2012) · 2022Article
- Structured elements drive extensive circular RNA translation.Molecular cell · 2021Article
- 18S rRNA variability maps reveal three highly divergent, conserved motifs within Rotifera.BMC ecology and evolution · 2021Article
- Characterization of a green Stentor with symbiotic algae growing in an extremely oligotrophic environment and storing large amounts of starch granules in its cytoplasm.Scientific reports · 2021Article
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- Pediludiella daitoensis gen. et sp. nov. (Scenedesmaceae, Chlorophyceae), a large coccoid green alga isolated from a Loxodes ciliate.Scientific reports · 2020Article
- Unassigned diversity of planktonic foraminifera from environmental sequencing revealed as known but neglected species.PloS one · 2019Article
- Genetic and morphological divergence in the warm-water planktonic foraminifera genus Globigerinoides.PloS one · 2019Article
- Filling gaps in the microsporidian tree: rDNA phylogeny of Chytridiopsis typographi (Microsporidia: Chytridiopsida).Parasitology research · 2019Article
- A New Molecular Approach Based on the Secondary Structure of Ribosomal RNA for Phylogenetic Analysis of Mobilid Ciliates.Current microbiology · 2018Article
- Genomic Survey of a Hyperparasitic Microsporidian Amphiamblys sp. (Metchnikovellidae).Genome biology and evolution · 2017Article
- New Comparative Analysis Based on the Secondary Structure of SSU-rRNA Gene Reveals the Evolutionary Trend and the Family-Genus Characters of Mobilida (Ciliophora, Peritrichia).Current microbiology · 2015Article
- Divergence thresholds and divergent biodiversity estimates: can metabarcoding reliably describe zooplankton communities?Ecology and evolution · 2015Article
- Computing the origin and evolution of the ribosome from its structure - Uncovering processes of macromolecular accretion benefiting synthetic biology.Computational and structural biotechnology journal · 2015Review
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relative substitution rate of each nucleotide site in bacterial small subunit rRNA, large subunit rRNA and 5S rRNA was calculated from sequence alignments for each molecule. Two-dimensional and three-dimensional variability maps of the rRNAs were obtained by plotting the substitution rates on secondary structure models and on the tertiary structure of the rRNAs available from X-ray diffraction results. This showed that the substitution rates are generally low near the centre of the ribosome, where the nucleotides essential for its function are situated, and that they increase towards the surface. An inventory was made of insertions characteristic of the Archaea, Bacteria and Eucarya domains, and for additional insertions present in specific eukaryotic taxa. All these insertions occur at the ribosome surface. The taxon-specific insertions seem to arise randomly in the eukaryotic evolutionary tree, without any phylogenetic relatedness between the taxa possessing them.
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