Trial reportIntensive care medicine2001
Effects of nasal continuous positive airway pressure (NCPAP) on breathing pattern in spontaneously breathing premature newborn infants.
Trial report in Intensive care medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07476404 (Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy: A Retrospective Cohort Study
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of time and body position on ventilation in premature infants.Pediatric research · 2016Trial
- Is volume and leak monitoring feasible during nasopharyngeal continuous positive airway pressure in neonates?Intensive care medicine · 2009Trial
- Influence of three nasal continuous positive airway pressure devices on breathing pattern in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2007Trial
- Adverse perinatal outcomes associated with respiratory distress syndrome in preterm infants: a retrospective analysis.Italian journal of pediatrics · 2025Article
- Development of CPAP Overlay Interfaces for Efficient Administration of Aerosol Surfactant Therapy to Preterm Infants.AAPS PharmSciTech · 2025Article
- Article
- The Effect of a Higher Bias Gas Flow on Imposed T-Piece Resistance and Breathing in Preterm Infants at Birth.Frontiers in pediatrics · 2022Article
- Article
- Hypoxic events and concomitant factors in preterm infants on non-invasive ventilation.Journal of clinical monitoring and computing · 2017Article
- Thoracoabdominal Asynchrony Is Not Associated with Oxyhemoglobin Saturation in Recovering Premature Infants.Neonatology · 2017Observational
- Feasibility of neurally adjusted positive end-expiratory pressure in rabbits with early experimental lung injury.BMC anesthesiology · 2015Article
- Article
- The role of surfactant and non-invasive mechanical ventilation in early management of respiratory distress syndrome in premature infants.World journal of pediatrics : WJP · 2014Review
- Obstructive sleep apnea in infants.American journal of respiratory and critical care medicine · 2012Review
- Long-term outcome of preterm infants treated with nasal continuous positive airway pressure.European journal of pediatrics · 2007Article
- Nasal CPAP for neonates: what do we know in 2003?Archives of disease in childhood. Fetal and neonatal edition · 2003Review
- Nasal CPAP in preterm infants--does it work and how?Intensive care medicine · 2001Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the study was to assess the influence of nasal continuous positive airway pressure (NCPAP) on breathing pattern in preterm newborns.
designProspective study.
settingNeonatal intensive care unit. PATIENTS: Ten premature newborn infants on NCPAP (gestational age range from 27 to 32 weeks, mean birth weight 1300+/-460 g) admitted in our neonatal intensive care unit (NICU) for respiratory distress syndrome.
methodsBreathing patterns and changes in lung volumes level were obtained using respiratory inductive plethysmography (RIP), at random CPAP levels (0, 2, 4, 6 and 8 cmH2O). Raw data were analysed for end-expiratory lung volume level (EELV-level), tidal volume (Vt), respiratory rate, phase angle and labour breathing index (LBI).
resultsCPAP increased EELV-level by 2.1+/-0.3xVt from 0 to 8 cmH2O ( p<0.01). Vt increased by 43% from CPAP of 0 cmH2O to CPAP of 8 cmH2O ( p<0.01). We also found that CPAP lowered the phase angle (from 76+/-21 degrees at CPAP of 0 cmH2O to 30+/-15 degrees at CPAP of 8 cmH2O; p<0.01 ) and LBI (from 1.7+/-0.8 at CPAP of 0 cmH2O to 1.2+/-0.3 at CPAP of 8 cmH2O; p<0.05).
conclusionNCPAP improves the breathing strategy of premature infants with respiratory failure, as reflected by improved thoraco-abdominal synchrony, increased Vt and reduction of the LBI. This effect is associated with an increase in EELV-level with CPAP level. However, further investigations are necessary to establish the best CPAP level that ensures both safety and efficiency.
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