ReviewThorax2002
Does environmental endotoxin exposure prevent asthma?
Review in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 153 citations in OpenAlex.
- Lung CD4Cell reports · 2025Article
- Radiation-Detoxified Form of Endotoxin Effectively Activates ThInternational journal of molecular sciences · 2024Article
- Respiratory symptoms and pulmonary function impairment among textile industry workers in Alexandria, Egypt.Journal of public health in Africa · 2023Article
- Characterizing Inflammatory Cell Asthma Associated Phenotypes in Dental Health Workers Using Cytokine Profiling.Frontiers in allergy · 2021Article
- Associations between household airborne culturable fungi and allergies and airway illnesses in childhood in Shanghai, China.Environmental science and pollution research international · 2020Article
- Indoor Endotoxin Exposure and Ambient Air Pollutants Interact on Asthma Outcomes.American journal of respiratory and critical care medicine · 2019Article
- Relationship of environmental disturbances and the infectious potential of fungi.Microbiology (Reading, England) · 2018Review
- Occupational Animal Allergy.Current allergy and asthma reports · 2018Review
- Density assessment and mapping of microorganisms around a biocomposting plant in Sanandaj, Iran.Environmental monitoring and assessment · 2017Article
- Association of macrophage migration inhibitory factor promoter polymorphism -173G/C with susceptibility to childhood asthma.Central-European journal of immunology · 2016Article
- Risk factors associated with asthma phenotypes in dental healthcare workers.American journal of industrial medicine · 2013Article
- The Head-off Environmental Asthma in Louisiana (HEAL) study--methods and study population.Environmental health perspectives · 2012Article
- Indoor environmental exposures for children with asthma enrolled in the HEAL study, post-Katrina New Orleans.Environmental health perspectives · 2012Article
- Environmental epigenetics of asthma: an update.The Journal of allergy and clinical immunology · 2010Review
- Hay fever and asthma symptoms in conventional and organic farmers in The Netherlands.Occupational and environmental medicine · 2007Article
- Health effects of airborne exposures from concentrated animal feeding operations.Environmental health perspectives · 2007Article
- Specific fungal exposures, allergic sensitization, and rhinitis in infants.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2006Article
- Acute blood neutrophilia induced by short-term compost dust exposure in previously unexposed healthy individuals.International archives of occupational and environmental health · 2006Article
- Airborne endotoxin is associated with respiratory illness in the first 2 years of life.Environmental health perspectives · 2006Article
- Too clean, or not too clean: the hygiene hypothesis and home hygiene.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2006Review
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evidence as to whether exposure to environmental airborne endotoxin plays a protective or an inducing role in the development of asthma is reviewed. Studies of endotoxin and atopy, endotoxin and asthma, and farming and asthma are considered and, in each instance, a distinction is made between evidence of primary causation and evidence of secondary causation. It is concluded that, although it is plausible that bacterial endotoxin may protect against the development of asthma, there is considerable reason for caution regarding this hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.