ArticleMolecular biology of the cell2002
Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 90 citations in OpenAlex.
- Structure and function of the keratin 17 tail domain associated with keratin intermediate filament organization.European journal of cell biology · 2025Article
- Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments.Cell reports · 2024Article
- From Strain Stiffening to Softening-Rheological Characterization of Keratins 8 and 18 Networks Crosslinked via Electron Irradiation.Polymers · 2022Article
- Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy.eLife · 2021Article
- Functional cell death, corneoptosis, requires temporally controlled intracellular acidification.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A unique mode of keratinocyte death requires intracellular acidification.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Novel keratinolytic enzymes, discovered from a talented and efficient bacterial keratin degrader.Scientific reports · 2020Article
- Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16.Nature communications · 2017Article
- Microbial decomposition of keratin in nature-a new hypothesis of industrial relevance.Applied microbiology and biotechnology · 2016Review
- Vimentin is necessary for colony growth of human diploid keratinocytes.Histochemistry and cell biology · 2015Article
- Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.The Journal of investigative dermatology · 2014Article
- Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.The Journal of biological chemistry · 2014Article
- Article
- The expanding significance of keratin intermediate filaments in normal and diseased epithelia.Current opinion in cell biology · 2013Review
- Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.Biophysical journal · 2012Article
- Properties of intermediate filament networks assembled from keratin 8 and 18 in the presence of Mg²+.Biophysical journal · 2012Article
- Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.Journal of cell science · 2012Article
- A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration.Developmental cell · 2012Article
- Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.Experimental cell research · 2011Article
- Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.BMC cancer · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most type I and II keratin genes are spatially and temporally regulated in a pairwise manner in epithelial tissues, where they represent the major structural proteins. Epithelia can be partitioned into simple (single-layered) and complex (multilayered) types. We compared the structural and mechanical properties of natural keratin polymers occurring in complex (K5-K14) and simple (K8-K18) epithelia. The intrinsic properties of these distantly related keratin filaments, whether dispersed or bundled in vitro, were surprisingly similar in all respects when at high polymer concentration. When type I and II assembly partners were switched to give rise to mismatched polymers (K5-K18; K8-K14), the interfilament interactions, which determine the structural and mechanical properties of keratin polymers, were significantly altered. We also show that a K5-K16 polymer exhibits lesser elasticity than K5- K14, which may help explain the inability of K16 to fully rescue the skin blistering characteristic of K14 null mice. The property of self-interaction exhibited by keratin filaments is likely to assist their function in vivo and may account for the relative paucity of cytoplasmic and keratin-specific cross-linkers. Our findings underscore the fundamental importance of pairwise polymerization and have implications for the functional significance of keratin sequence diversity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.