ArticleMolecular biology of the cell2002
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 183 citations in OpenAlex.
- Polarity protein Par6 facilitates the processive phosphorylation of Lgl via a dynamic interaction with aPKC.Communications biology · 2025Article
- Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals.Frontiers in cell and developmental biology · 2022Review
- The Scribble Complex PDZ Proteins in Immune Cell Polarities.Journal of immunology research · 2020Review
- Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex.The Journal of cell biology · 2019Article
- Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.American journal of physiology. Cell physiology · 2018Article
- AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus.Nature communications · 2018Article
- Phosphoinositides and Membrane Targeting in Cell Polarity.Cold Spring Harbor perspectives in biology · 2018Review
- Article
- Mechanisms of radial glia progenitor cell lineage progression.FEBS letters · 2017Review
- Crosstalk of cell polarity signaling pathways.Protoplasma · 2017Review
- Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.Oncotarget · 2016Article
- MicroRNA Regulation of Epithelial to Mesenchymal Transition.Journal of clinical medicine · 2016Review
- Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons.Bioarchitecture · 2016Article
- Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate.BioMed research international · 2016Article
- Cell Fate Decision Making through Oriented Cell Division.Journal of developmental biology · 2015Article
- The Mammalian Blood-Testis Barrier: Its Biology and Regulation.Endocrine reviews · 2015Review
- Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.International journal of molecular medicine · 2015Article
- Expression of polarity genes in human cancer.Cancer informatics · 2015Article
- Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development.International journal of biological sciences · 2015Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Drosophila tumor suppressor protein lethal (2) giant larvae [l(2)gl] is involved in the establishment of epithelial cell polarity during development. Recently, a yeast homolog of the protein has been shown to interact with components of the post-Golgi exocytic machinery and to regulate a late step in protein secretion. Herein, we characterize a mammalian homolog of l(2)gl, called Mlgl, in the epithelial cell line Madin-Darby canine kidney (MDCK). Consistent with a role in cell polarity, Mlgl redistributes from a cytoplasmic localization to the lateral membrane after contact-naive MDCK cells make cell-cell contacts and establish a polarized phenotype. Phosphorylation within a highly conserved region of Mlgl is required to restrict the protein to the lateral domain, because a recombinant phospho-mutant is distributed in a nonpolar manner. Membrane-bound Mlgl from MDCK cell lysates was coimmunoprecipitated with syntaxin 4, a component of the exocytic machinery at the basolateral membrane, but not with other plasma membrane soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins that are either absent from or not restricted to the basolateral membrane domain. These data suggest that Mlgl contributes to apico-basolateral polarity by regulating basolateral exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.