ArticleMolecular biology of the cell2002
Hyphal elongation is regulated independently of cell cycle in Candida albicans.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 108 citations in OpenAlex.
- Adaptive evolution ofmBio · 2025Article
- Candida albicans and Antifungal Peptides.Infectious diseases and therapy · 2023Article
- Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity.Antimicrobial agents and chemotherapy · 2020Article
- Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogenMolecular biology of the cell · 2019Article
- Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development.Scientific reports · 2016Article
- Candida albicans Kinesin Kar3 Depends on a Cik1-Like Regulatory Partner Protein for Its Roles in Mating, Cell Morphogenesis, and Bipolar Spindle Formation.Eukaryotic cell · 2015Article
- Novel mechanism coupling cyclic AMP-protein kinase A signaling and golgi trafficking via Gyp1 phosphorylation in polarized growth.Eukaryotic cell · 2014Article
- A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.PLoS biology · 2014Article
- Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- AI-2 of Aggregatibacter actinomycetemcomitans inhibits Candida albicans biofilm formation.Frontiers in cellular and infection microbiology · 2014Article
- Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth.Molecular biology of the cell · 2012Article
- Candida and invasive candidiasis: back to basics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Review
- Candida albicans: A Model Organism for Studying Fungal Pathogens.ISRN microbiology · 2012Article
- Identification of cell cycle-regulated, putative hyphal genes in Candida albicans.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2012Article
- Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans.Molecular biology of the cell · 2012Article
- A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans.PLoS pathogens · 2012Article
- Growth of Candida albicans hyphae.Nature reviews. Microbiology · 2011Review
- Regulatory circuitry governing fungal development, drug resistance, and disease.Microbiology and molecular biology reviews : MMBR · 2011Review
- Orthologues of the anaphase-promoting complex/cyclosome coactivators Cdc20p and Cdh1p are important for mitotic progression and morphogenesis in Candida albicans.Eukaryotic cell · 2011Article
- G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism for apical growth during hyphal morphogenesis in Candida albicans is unknown. Studies from Saccharomyces cerevisiae indicate that cell morphogenesis may involve cell cycle regulation by cyclin-dependent kinase. To examine whether this is the mechanism for hyphal morphogenesis, the temporal appearance of different spindle pole body and spindle structures, the cell cycle-regulated rearrangements of the actin cytoskeleton, and the phosphorylation state of the conserved Tyr19 of Cdc28 during the cell cycle were compared and found to be similar between yeast and serum-induced hyphal apical cells. These data suggest that hyphal elongation is not mediated by altering cell cycle progression or through phosphorylation of Tyr19 of Cdc28. We have also shown that germ tubes can evaginate before spindle pole body duplication, chitin ring formation, and DNA replication. Similarly, tip-associated actin polarization in each hypha occurs before the events of the G(1)/S transition and persists throughout the cell cycle, whereas cell cycle-regulated actin assemblies come and go. We have also shown that cells in phases other than G(1) can be induced to form hyphae. Hyphae induced from G(1) cells have no constrictions, and the first chitin ring is positioned in the germ tube at various distances from the base. Hyphae induced from budded cells have a constriction and a chitin ring at the bud neck, beyond which the hyphae continue to elongate with no further constrictions. Our data suggest that hyphal elongation and cell cycle morphogenesis programs are uncoupled, and each contributes to different aspects of cell morphogenesis.
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