ArticleMolecular biology of the cell2002
Testing a mathematical model of the yeast cell cycle.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed, 264 citations in OpenAlex.
- Cell Cycle Complexity: Exploring the Structure of Persistent Subsystems in 414 Models.Biomedicines · 2024Article
- Modeling the START transition in the budding yeast cell cycle.PLoS computational biology · 2024Article
- The bistable mitotic switch in fission yeast.Molecular biology of the cell · 2024Article
- The oscillation of mitotic kinase governs cell cycle latches in mammalian cells.Journal of cell science · 2024Article
- Systems Pharmacodynamic Model of Combined Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways.Journal of pharmaceutical sciences · 2024Article
- A yeast cell cycle model integrating stress, signaling, and physiology.FEMS yeast research · 2022Article
- Mitotic kinase oscillation governs the latching of cell cycle switches.Current biology : CB · 2022Article
- Mad3 modulates the GScience advances · 2022Article
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- Bistability in fatty-acid oxidation resulting from substrate inhibition.PLoS computational biology · 2021Article
- Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- The switching mechanism of the bacterial rotary motor combines tight regulation with inherent flexibility.The EMBO journal · 2021Article
- Misuse of the Michaelis-Menten rate law for protein interaction networks and its remedy.PLoS computational biology · 2020Review
- Emergence of cooperative bistability and robustness of gene regulatory networks.PLoS computational biology · 2020Article
- Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs.NPJ systems biology and applications · 2020Article
- A hybrid stochastic model of the budding yeast cell cycle.NPJ systems biology and applications · 2020Article
- A Single Light-Responsive Sizer Can Control Multiple-Fission Cycles in Chlamydomonas.Current biology : CB · 2020Article
- Multisite phosphorylation code of CDK.Nature structural & molecular biology · 2019Article
- Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress.Life science alliance · 2019Article
- Control of Eukaryotic DNA Replication Initiation-Mechanisms to Ensure Smooth Transitions.Genes · 2019Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We derived novel, testable predictions from a mathematical model of the budding yeast cell cycle. A key qualitative prediction of bistability was confirmed in a strain simultaneously lacking cdc14 and G1 cyclins. The model correctly predicted quantitative dependence of cell size on gene dosage of the G1 cyclin CLN3, but it incorrectly predicted strong genetic interactions between G1 cyclins and the anaphase-promoting complex specificity factor Cdh1. To provide constraints on model generation, we determined accurate concentrations for the abundance of all nine cyclins as well as the inhibitor Sic1 and the catalytic subunit Cdc28. For many of these we determined abundance throughout the cell cycle by centrifugal elutriation, in the presence or absence of Cdh1. In addition, perturbations to the Clb-kinase oscillator were introduced, and the effects on cyclin and Sic1 levels were compared between model and experiment. Reasonable agreement was obtained in many of these experiments, but significant experimental discrepancies from the model predictions were also observed. Thus, the model is a strong but incomplete attempt at a realistic representation of cell cycle control. Constraints of the sort developed here will be important in development of a truly predictive model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.