ArticleMolecular biology of the cell2002
Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.Nature communications · 2021Article
- Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells.Oncogene · 2019Article
- Impact of PKCε downregulation on autophagy in glioblastoma cells.BMC cancer · 2018Article
- Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens.Journal of neuroscience research · 2017Article
- Review
- Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions.BMC biochemistry · 2016Article
- Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).European journal of medicinal chemistry · 2015Article
- Targeting the actin cytoskeleton: selective antitumor action via trapping PKCɛ.Cell death & disease · 2014Article
- Article
- PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.Journal of leukocyte biology · 2013Article
- From Drosophila development to adult: clues to Notch function in long-term memory.Frontiers in cellular neuroscience · 2013Article
- Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation.Molecular biology of the cell · 2011Article
- The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.Frontiers of medicine · 2011Review
- Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.The Journal of biological chemistry · 2011Article
- Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome.PloS one · 2010Article
- Article
- Proteomic analysis of differential proteins related to the neuropathic pain and neuroprotection in the dorsal root ganglion following its chronic compression in rats.Experimental brain research · 2008Article
- A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.The Journal of biological chemistry · 2008Article
- Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia.Experimental eye research · 2008Article
- A novel PIP2 binding of epsilonPKC and its contribution to the neurite induction ability.Journal of neurochemistry · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpression of full-length PKCepsilon is suppressed if serum is removed from the cultures or if an actin-binding site is deleted from the protein. A peptide corresponding to the PKCepsilon actin-binding site suppresses neurite outgrowth during neuronal differentiation and outgrowth elicited by PKCepsilon overexpression. Neither serum removal, deletion of the actin-binding site, nor introduction of the peptide affects neurite induction by the isolated regulatory domain. Membrane targeting by myristoylation renders full-length PKCepsilon independent of both serum and the actin-binding site, and PKCepsilon colocalized with F-actin at the cortical cytoskeleton during neurite outgrowth. These results demonstrate that the actin-binding site is of importance for signals acting on PKCepsilon in a pathway leading to neurite outgrowth. Localization of PKCepsilon to the plasma membrane and/or the cortical cytoskeleton is conceivably important for its effect on neurite outgrowth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.