ArticleMolecular and cellular biology2002
Unique motif for nucleolar retention and nuclear export regulated by phosphorylation.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.PloS one · 2015Article
- The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.Journal of virology · 2013Article
- Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.Journal of virology · 2012Article
- Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking.Journal of virology · 2012Article
- Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection.Antiviral research · 2011Article
- Characterization and prediction of protein nucleolar localization sequences.Nucleic acids research · 2010Article
- Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells.Virus research · 2010Article
- Shiga toxin is transported into the nucleoli of intestinal epithelial cells via a carrier-dependent process.Toxins · 2010Article
- The nucleolus and viral infection.Virologica Sinica · 2010Review
- Involvement of the nucleolus in replication of human viruses.Reviews in medical virology · 2009Review
- Nucleolar targeting: the hub of the matter.EMBO reports · 2009Review
- Nucleolin is required for an efficient herpes simplex virus type 1 infection.Journal of virology · 2008Article
- Nucleolar trafficking of nucleostemin family proteins: common versus protein-specific mechanisms.Molecular and cellular biology · 2007Article
- Identification of a common subnuclear localization signal.Molecular biology of the cell · 2007Article
- Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors.The Plant cell · 2006Article
- Delineation and modelling of a nucleolar retention signal in the coronavirus nucleocapsid protein.Traffic (Copenhagen, Denmark) · 2006Article
- Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function.Journal of virology · 2005Article
- Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.Molecular and cellular biology · 2004Article
- Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death.Oncogene · 2004Article
- EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.Oncogene · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By microinjecting purified glutathione S-transferase linked to all or parts of herpes simplex virus type 1 US11 protein into either the nucleus or the cytoplasm, we have demonstrated that this nucleolar protein exhibits a new type of localization signal controlling both retention in nucleoli and export to the cytoplasm. Saturated mutagenesis combined with computer modeling allowed us to draw the fine-structure map of this domain, revealing a new proline-rich motif harboring both activities, which are temperature dependent and regulated by phosphorylation. Finally, crossing the nuclear pore complex from the cytoplasm to the nucleus is an energy-dependent process for US11 protein, while getting to nucleoli through the nucleoplasm is energy independent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.