ArticleJournal of muscle research and cell motility2001
MRF4 protein expression in regenerating rat muscle.
Article in Journal of muscle research and cell motility, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Hypoxic Signaling in Skeletal Muscle Maintenance and Regeneration: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment.Scientific reports · 2021Article
- IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts.International journal of molecular sciences · 2019Article
- Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish.BMC evolutionary biology · 2018Article
- Gene Expression Profiling in Slow-Type Calf Soleus Muscle of 30 Days Space-Flown Mice.PloS one · 2017Article
- Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair.Parasites & vectors · 2008Article
- Regulation of skeletal muscle differentiation in fibroblasts by exogenous MyoD gene in vitro and in vivo.Molecular and cellular biochemistry · 2007Article
- A selective role for MRF4 in innervated adult skeletal muscle: Na(V) 1.4 Na+ channel expression is reduced in MRF4-null mice.Gene expression · 2005Article
- Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle.Histochemistry and cell biology · 2004Article
- Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factor MRF4.The American journal of pathology · 2003Article
- The expression profile of myogenic transcription factors in satellite cells from denervated rat muscle.Brain pathology (Zurich, Switzerland) · 2002Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myogenic transcription factors of the MyoD family are not expressed in normal adult skeletal muscle. They are upregulated at the transcript and protein levels in a precisely coordinated manner during regeneration. While the cellular distribution of MyoD, myf-5, and myogenin expression in regenerating muscle is well documented, little is known about the exact localization of MRF4. It was the aim of this study to monitor the cellular distribution of MRF4 protein during regeneration. The soleus muscle of 6-week-old male Wistar rats was devascularized and allowed to regenerate for 2, 5, 10 or 14 days. Immunostaining revealed the presence of MRF4 throughout the time periods studied. Expression was detected in the nuclei of myofibers which had survived the devascularization procedure 2 days after necrosis was induced. In nuclei of newly formed myotubes and young myofibers, MRF4 was co-expressed with MyoD and myogenin. MRF4 protein was absent from satellite cells (SC), with anti-M-cadherin being used as a SC marker. Taken together, our results demonstrate that MRF4 protein expression in regenerated fibers is restricted to the time around and after fusion. The absence of MRF4 protein in SC suggests that the role of MRF4 during regeneration is distinct from myf-5, MyoD, and myogenin.
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