ArticleJournal of bacteriology2002
act operon control of developmental gene expression in Myxococcus xanthus.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- The NmpRSTU multi-component signaling system ofJournal of bacteriology · 2025Article
- Identifying the Gene Regulatory Network of the Starvation-Induced Transcriptional Activator Nla28.Journal of bacteriology · 2022Article
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes.Journal of bacteriology · 2016Review
- The enhancer binding protein Nla6 regulates developmental genes that are important for Myxococcus xanthus sporulation.Journal of bacteriology · 2015Article
- Fatty acids from membrane lipids become incorporated into lipid bodies during Myxococcus xanthus differentiation.PloS one · 2014Article
- Specificity residues determine binding affinity for two-component signal transduction systems.mBio · 2013Article
- Are Myxobacteria intelligent?Frontiers in microbiology · 2013Article
- The Nla28S/Nla28 two-component signal transduction system regulates sporulation in Myxococcus xanthus.Journal of bacteriology · 2012Article
- A cascade of coregulating enhancer binding proteins initiates and propagates a multicellular developmental program.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Identification of enhancer binding proteins important for Myxococcus xanthus development.Journal of bacteriology · 2010Article
- ScrG, a GGDEF-EAL protein, participates in regulating swarming and sticking in Vibrio parahaemolyticus.Journal of bacteriology · 2007Article
- Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.Journal of bacteriology · 2007Article
- Mutations of the act promoter in Myxococcus xanthus.Journal of bacteriology · 2007Article
- Sigma54 enhancer binding proteins and Myxococcus xanthus fruiting body development.Journal of bacteriology · 2004Article
- Mutational analysis of the Myxococcus xanthus Omicron4499 promoter region reveals shared and unique properties in comparison with other C-signal-dependent promoters.Journal of bacteriology · 2004Article
- Waves and aggregation patterns in myxobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Mutational analysis of the Myxococcus xanthus Omega4400 promoter region provides insight into developmental gene regulation by C signaling.Journal of bacteriology · 2004Article
- Dynamics of fruiting body morphogenesis.Journal of bacteriology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell-bound C-signal guides the building of a fruiting body and triggers the differentiation of myxospores. Earlier work has shown that transcription of the csgA gene, which encodes the C-signal, is directed by four genes of the act operon. To see how expression of the genes encoding components of the aggregation and sporulation processes depends on C-signaling, mutants with loss-of-function mutations in each of the act genes were investigated. These mutations were found to have no effect on genes that are normally expressed up to 3 h into development and are C-signal independent. Neither the time of first expression nor the rate of expression increase was changed in actA, actB, actC, or actD mutant strains. Also, there was no effect on A-signal production, which normally starts before 3 h. By contrast, the null act mutants have striking defects in C-signal production. These mutations changed the expression of four gene reporters that are related to aggregation and sporulation and are expressed at 6 h or later in development. The actA and actB null mutations substantially decreased the expression of all these reporters. The other act null mutations caused either premature expression to wild-type levels (actC) or delayed expression (actD), which ultimately rose to wild-type levels. The pattern of effects on these reporters shows how the C-signal differentially regulates the steps that together build a fruiting body and differentiate spores within it.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.