ArticleJournal of bacteriology2002
Regulation and adaptive evolution of lactose operon expression in Lactobacillus delbrueckii.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Isolation, characterization and comparative genomics of potentially probiotic Lactiplantibacillus plantarum strains from Indian foods.Scientific reports · 2022Article
- Modulation of Bacterial Fitness and Virulence Through Antisense RNAs.Frontiers in cellular and infection microbiology · 2020Review
- The lactose operon from Lactobacillus casei is involved in the transport and metabolism of the human milk oligosaccharide core-2 N-acetyllactosamine.Scientific reports · 2018Article
- The art of strain improvement of industrial lactic acid bacteria without the use of recombinant DNA technology.Microbial cell factories · 2014Review
- Lactobacillus delbrueckii ssp. lactis and ssp. bulgaricus: a chronicle of evolution in action.BMC genomics · 2014Article
- The sensitivity and significance analysis of parameters in the model of pH regulation on lactic acid production by Lactobacillus bulgaricus.BMC bioinformatics · 2014Article
- Homodimeric β-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus DSM 20081: expression in Lactobacillus plantarum and biochemical characterization.Journal of agricultural and food chemistry · 2012Article
- Comment on: Successful therapy of treatment-emergent, non-clonal daptomycin-non-susceptible Enterococcus faecium infections.The Journal of antimicrobial chemotherapy · 2012Article
- Systems solutions by lactic acid bacteria: from paradigms to practice.Microbial cell factories · 2011Review
- In silico prediction of horizontal gene transfer events in Lactobacillus bulgaricus and Streptococcus thermophilus reveals protocooperation in yogurt manufacturing.Applied and environmental microbiology · 2009Article
- A generic approach to identify Transcription Factor-specific operator motifs; Inferences for LacI-family mediated regulation in Lactobacillus plantarum WCFS1.BMC genomics · 2008Article
- The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Genetic diversity in the lactose operons of Lactobacillus helveticus strains and its relationship to the role of these strains as commercial starter cultures.Applied and environmental microbiology · 2005Article
- Heat shock treatment increases the frequency of loss of an erythromycin resistance-encoding transposable element from the chromosome of Lactobacillus crispatus CHCC3692.Applied and environmental microbiology · 2003Article
- IS981-mediated adaptive evolution recovers lactate production by ldhB transcription activation in a lactate dehydrogenase-deficient strain of Lactococcus lactis.Journal of bacteriology · 2003Article
- Unusual organization for lactose and galactose gene clusters in Lactobacillus helveticus.Applied and environmental microbiology · 2003Article
- Extent of genetic lesions of the arginine and pyrimidine biosynthetic pathways in Lactobacillus plantarum, L. paraplantarum, L. pentosus, and L. casei: prevalence of CO(2)-dependent auxotrophs and characterization of deficient arg genes in L. plantarum.Applied and environmental microbiology · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactobacillus delbrueckii subsp. bulgaricus and L. delbrueckii subsp. lactis are both used in the dairy industry as homofermentative lactic acid bacteria in the production of fermented milk products. After selective pressure for the fast fermentation of milk in the manufacture of yogurts, L. delbrueckii subsp. bulgaricus loses its ability to regulate lac operon expression. A series of mutations led to the constitutive expression of the lac genes. A complex of insertion sequence (IS) elements (ISL4 inside ISL5), inserted at the border of the lac promoter, induced the loss of the palindromic structure of one of the operators likely involved in the binding of regulatory factors. A lac repressor gene was discovered downstream of the beta-galactosidase gene of L. delbrueckii subsp. lactis and was shown to be inactivated by several mutations in L. delbrueckii subsp. bulgaricus. Regulatory mechanisms of the lac gene expression of L. delbrueckii subsp. bulgaricus and L. delbrueckii subsp. lactis were compared by heterologous expression in Lactococcus lactis of the two lac promoters in front of a reporter gene (beta-glucuronidase) in the presence or absence of the lac repressor gene. Insertion of the complex of IS elements in the lac promoter of L. delbrueckii subsp. bulgaricus increased the promoter's activity but did not prevent repressor binding; rather, it increased the affinity of the repressor for the promoter. Inactivation of the lac repressor by mutations was then necessary to induce the constitutive expression of the lac genes in L. delbrueckii subsp. bulgaricus.
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