ArticleBiophysical journal2002
Membrane dipole potential modulates proton conductance through gramicidin channel: movement of negative ionic defects inside the channel.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Alteration of Lipid Bilayer Electrical Potential by Phytochemicals and Synthetic Analogs: Implications for Cellular Function.Biomolecules · 2026Review
- Review
- Proton transfer reactions: From photochemistry to biochemistry and bioenergetics.BBA advances · 2023Article
- Methanol Accelerates DMPC Flip-Flop and Transfer: A SANS Study on Lipid Dynamics.Biophysical journal · 2019Article
- Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics.Scientific reports · 2018Article
- Assessing anesthetic activity through modulation of the membrane dipole potential.Journal of lipid research · 2017Article
- The dipole potential correlates with lipid raft markers in the plasma membrane of living cells.Journal of lipid research · 2017Article
- Review
- Two types of syringomycin E channels in sphingomyelin-containing bilayers.European biophysics journal : EBJ · 2016Article
- Stigmatellin probes the electrostatic potential in the QB site of the photosynthetic reaction center.Biophysical journal · 2015Article
- Investigation of channel-forming activity of polyene macrolide antibiotics in planar lipid bilayers in the presence of dipole modifiers.Acta naturae · 2014Article
- The interaction of dipole modifiers with amphotericin-ergosterol complexes. Effects of phospholipid and sphingolipid membrane composition.European biophysics journal : EBJ · 2014Article
- Article
- N-terminally glutamate-substituted analogue of gramicidin A as protonophore and selective mitochondrial uncoupler.PloS one · 2012Article
- Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes.Journal of the Royal Society, Interface · 2011Article
- Article
- Meet me on the other side: trans-bilayer modulation of a model voltage-gated ion channel activity by membrane electrostatics asymmetry.PloS one · 2011Article
- Modeling negative ion defect migration through the gramicidin A channel.Journal of molecular modeling · 2009Article
- Specific inhibition of the plasmodial surface anion channel by dantrolene.Eukaryotic cell · 2006Article
- Partitioning of tetrachlorophenol into lipid bilayers and sarcoplasmic reticulum: effect of length of acyl chains, carbonyl group of lipids and biomembrane structure.The Journal of membrane biology · 2005Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
The effect of membrane dipole potential on gramicidin channel activity in bilayer lipid membranes (BLMs) was studied. Remarkably, it appeared that proton conductance of gramicidin A (gA) channels responded to modulation of the dipole potential oppositely as compared with gA alkali metal cation conductance. In particular, the addition of phloretin, known to reduce the membrane dipole potential, resulted in a decrease in gA proton conductance, on one hand, and an increase in gA alkali metal conductance, on the other hand, whereas 6-ketocholestanol, the agent raising the membrane dipole potential, provoked an increase in gA proton conductance as opposed to a decrease in the alkali metal cation conductance. The peculiarity of the 6-ketocholestanol effect consisted in its dependence on the H(+) concentration. The experiments with the impermeant dipolar compound, phloridzin, showed that the response of proton transport through gramicidin channels to varying the membrane dipole potential did not change qualitatively if the dipole potential of only one monolayer or both monolayers of the BLM was altered. In contrast to gA proton conductance, the single-channel lifetime changed similarly with varying the membrane dipole potential, regardless of the kind of permeant cations (protons or potassium ions). The results of this study could be tentatively accounted for by an assumption that one of the rate-limiting steps of proton conduction through gramicidin channels represents, in fact, movement of negatively charged species (negative ionic defects) across a membrane.
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