ArticleBiophysical journal2002
Carboxyl tail prevents yeast K(+) channel closure: proposal of an integrated model of TOK1 gating.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecular architecture of the fungal-specific potassium channel TOK1.Nature communications · 2026Article
- Transcriptional profiling of Zygosaccharomyces bailii early response to acetic acid or copper stress mediated by ZbHaa1.Scientific reports · 2018Article
- Feeling the hidden mechanical forces in lipid bilayer is an original sense.Proceedings of the National Academy of Sciences of the United States of America · 2014Review
- Regulation of cation balance in Saccharomyces cerevisiae.Genetics · 2013Review
- Ion channels in microbes.Physiological reviews · 2008Review
- Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity.The Biochemical journal · 2006Article
- Microbial K+ channels.The Journal of general physiology · 2005Review
- TOK homologue in Neurospora crassa: first cloning and functional characterization of an ion channel in a filamentous fungus.Eukaryotic cell · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
TOK1 encodes the channel responsible for the prominent outward K(+) current of the yeast plasma membrane. It can dwell in several impermeable states, including a rapidly transiting, K(+)-electromotive-force-dependent "R" (rectifying) state, a voltage-independent "IB" (interburst) state, and a set of [K(+)](ext) and voltage-dependent "C" (closed) states. Whereas evidence suggests that the C states result from the constriction of an inner gate at the cytosolic end of the pore, R is most likely an intrinsic gating property of the K(+) filter. Here, we present evidence that Tok1's carboxyl-tail domain also plays an intimate role in channel gating by dynamically preventing inner-gate closures. We present an integrated model of TOK1 gating in which the filter gate, inner gate, and carboxyl tail interact to produce the various phenomenological states. Both wild-type and tailless behaviors can be replicated using Monte Carlo computer simulations based on this model.
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