ArticleThe Journal of pharmacology and experimental therapeutics2002
Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.
Article in The Journal of pharmacology and experimental therapeutics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Extracellular ATP and its derivatives provide spatiotemporal guidance for bone adaptation to wide spectrum of physical forces.Bone reports · 2022Review
- Enlightening activation gating in P2X receptors.Purinergic signalling · 2022Review
- Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission.Neuropharmacology · 2015Article
- Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins.Antioxidants & redox signaling · 2014Review
- Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons.PloS one · 2014Article
- Heteromeric assembly of P2X subunits.Frontiers in cellular neuroscience · 2013Review
- Article
- Pharmacochemistry of the platelet purinergic receptors.Purinergic signalling · 2011Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Interaction and interrelation of P2X7 and P2X4 receptor complexes in mouse lung epithelial cells.Cellular and molecular life sciences : CMLS · 2010Article
- Mouse Leydig cells express multiple P2X receptor subunits.Purinergic signalling · 2009Article
- Functional interactions between P2X4 and P2X7 receptors from mouse salivary epithelia.The Journal of physiology · 2009Article
- P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors.European biophysics journal : EBJ · 2009Article
- Acid-sensitive ion channels and receptors.Handbook of experimental pharmacology · 2009Review
- Interaction of P2 purinergic receptors with cellular macromolecules.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- P2 receptor-mediated modulation of neurotransmitter release-an update.Purinergic signalling · 2007Article
- Molecular properties of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- Pharmacology of P2X channels.Pflugers Archiv : European journal of physiology · 2006Review
- Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rat P2X(1) and P2X(2) subunits were coexpressed in defolliculated Xenopus oocytes and the resultant P2X receptors studied under voltage-clamp conditions. Extracellular ATP elicited biphasic inward currents, involving an initial rapidly inactivating (P2X(1)-like) component and a later slowly inactivating (P2X(2)-like) component. The maximum amplitude of P2X(1)-like ATP responses was increased in some cells by lowering extracellular pH (from 7.5 to 6.5), whereas P2X(2)-like responses and those of homomeric rP2X(1) and rP2X(2) receptors were not changed by this treatment. Concentration-response (C/R) curves for ATP for pH-enhanced P2X(1)-like responses were biphasic, and clearly distinct from monophasic ATP C/R curves for homomeric rP2X(1) and rP2X(2) receptors. Under acidic (pH 5.5 and 6.5) and alkaline (pH 8.5) conditions, ATP C/R curves for P2X(1)-like responses showed increases in agonist potency and efficacy, compared with data at pH 7.5, but the same was not true of homomeric rP2X(1) and rP2X(2) receptors. ATP C/R curves for P2X(2)-like responses overlay C/R curves for homomeric rP2X(2) receptors, and determinations of agonist potency and efficacy were identical for P2X(2)-like and P2X(2) responses at all pH levels tested. Our results show that P2X(1)-like responses possessed the kinetics of homomeric P2X(1) receptors but an acid sensitivity different from homomeric P2X(1) and P2X(2) receptors. In contrast, the P2X(2)-like responses exactly matched the profile expected of homomeric P2X(2) receptors. Thus, coexpression of P2X(1) and P2X(2) subunits yielded a mixed population of homomeric and heteromeric P2X receptors, with a subpopulation of novel pH-sensitive P2X receptors showing identifiably unique properties that indicated the formation of heteromeric P2X(1/2) ion channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.