ArticleGenetics2002
Differential gene silencing by trans-heterochromatin in Drosophila melanogaster.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering.Molecular biology and evolution · 2016Article
- Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle.Cellular and molecular life sciences : CMLS · 2011Review
- Neighbourhood continuity is not required for correct testis gene expression in Drosophila.PLoS biology · 2010Article
- Paramutation in maize: RNA mediated trans-generational gene silencing.Current opinion in genetics & development · 2010Review
- High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.Epigenetics & chromatin · 2009Article
- Using molecular tethering to analyze the role of nuclear compartmentalization in the regulation of mammalian gene activity.Methods (San Diego, Calif.) · 2008Article
- Article
- Interplay of developmentally regulated gene expression and heterochromatic silencing in trans in Drosophila.Genetics · 2008Article
- Article
- Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica.PLoS pathogens · 2006Article
- The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.Leukemia · 2006Article
- Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica.Eukaryotic cell · 2005Article
- Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization.PLoS biology · 2005Article
- Sequence elements in cis influence heterochromatic silencing in trans.Molecular and cellular biology · 2005Article
- Heterochromatic self-association, a determinant of nuclear organization, does not require sequence homology in Drosophila.Genetics · 2003Article
- Transcriptional silencing of an amoebapore gene in Entamoeba histolytica: molecular analysis and effect on pathogenicity.Eukaryotic cell · 2003Article
- Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brown(Dominant) (bw(D)) allele contains a large insertion of heterochromatin leading to the trans-inactivation of the wild-type allele in bw(D)/bw(+) heterozygous flies. This silencing is correlated with the localization of bw(+) to a region of the interphase nucleus containing centric heterochromatin. We have used a series of transgene constructs inserted in the vicinity of the bw locus to demarcate both the extent of bw(D) influence along the chromosome and the relative sensitivities of various genes. Examples of regulatory regions that are highly sensitive, moderately sensitive, and insensitive were found. Additionally, by using the same transgene at increasing distances from the bw(D) insertion site in trans we were able to determine the range of influence of the heterochromatic neighborhood in terms of chromosomal distance. When the transgene was farther away from bw, there was, indeed, a tendency for it to be less trans-inactivated. However, insertion site also influenced silencing: a gene 86 kb away was trans-inactivated, while the same transgene 45 kb away was not. Thus location, distance, and gene-specific differences all influence susceptibility to trans-silencing near a heterochromatic neighborhood. These results have important implications for the ability of nuclear positioning to influence the expression of large blocks of a chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.