ArticleGenetics2002
The Ess1 prolyl isomerase is required for growth and morphogenetic switching in Candida albicans.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Oncogenic Hijacking of the PIN1 Signaling Network.Frontiers in oncology · 2019Review
- Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1.PLoS genetics · 2016Article
- Article
- Identification and functional analysis of AG1-IA specific genes of Rhizoctonia solani.Current genetics · 2014Article
- The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle.Biochimica et biophysica acta · 2014Review
- Role of Ess1 in growth, morphogenetic switching, and RNA polymerase II transcription in Candida albicans.PloS one · 2013Article
- Application of the systematic "DAmP" approach to create a partially defective C. albicans mutant.Fungal genetics and biology : FG & B · 2011Article
- Milestones in Candida albicans gene manipulation.Fungal genetics and biology : FG & B · 2011Review
- Restricted domain mobility in the Candida albicans Ess1 prolyl isomerase.Biochimica et biophysica acta · 2010Article
- Article
- Small family with key contacts: par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical research.Perspectives in medicinal chemistry · 2008Article
- Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.BMC genomics · 2006Article
- The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobility.Biochemistry · 2005Article
- Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe.Comparative and functional genomics · 2005Article
- Article
- Domainal organization of the lower eukaryotic homologs of the yeast RNA polymerase II core subunit Rpb7 reflects functional conservation.Nucleic acids research · 2004Article
- Article
- Molecular genetic and genomic approaches to the study of medically important fungi.Infection and immunity · 2003Review
- Peptidyl-prolyl isomerases: a new twist to transcription.EMBO reports · 2002Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Prolyl-isomerases (PPIases) are found in all organisms and are important for the folding and activity of many proteins. Of the 13 PPIases in Saccharomyces cerevisiae only Ess1, a parvulin-class PPIase, is essential for growth. Ess1 is required to complete mitosis, and Ess1 and its mammalian homolog, Pin1, interact directly with RNA polymerase II. Here, we isolate the ESS1 gene from the pathogenic fungus Candida albicans and show that it is functionally homologous to the S. cerevisiae ESS1. We generate conditional-lethal (ts) alleles of C. albicans ESS1 and use these mutations to demonstrate that ESS1 is essential for growth in C. albicans. We also show that reducing the dosage or activity of ESS1 blocks morphogenetic switching from the yeast to the hyphal and pseudohyphal forms under certain conditions. Analysis of double mutants of ESS1 and TUP1 or CPH1, two genes known to be involved in morphogenetic switching, suggests that ESS1 functions in the same pathway as CPH1 and upstream of or in parallel to TUP1. Given that switching is important for virulence of C. albicans, inhibitors of Ess1 might be useful as antifungal agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.