ArticleOncogene2002
The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis.International journal of molecular sciences · 2025Article
- Epigenetic regulation of embryonic ectoderm development in stem cell differentiation and transformation during ontogenesis.Cell proliferation · 2023Review
- Loss of microglial EED impairs synapse density, learning, and memory.Molecular psychiatry · 2022Article
- The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.Cells · 2021Review
- Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.Nature reviews. Cancer · 2016Review
- Epigenetic control of adult stem cell function.Nature reviews. Molecular cell biology · 2016Review
- Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.Cold Spring Harbor perspectives in medicine · 2016Review
- Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications.Medicinal research reviews · 2015Review
- Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes.Journal of autoimmunity · 2013Review
- Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms.Leukemia · 2013Review
- An efficient weighted graph strategy to identify differentiation associated genes in embryonic stem cells.PloS one · 2013Article
- PRC2 during vertebrate organogenesis: a complex in transition.Developmental biology · 2012Review
- A complex Polycomb issue: the two faces of EZH2 in cancer.Genes & development · 2012Article
- A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.Genes & development · 2012Article
- A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.PloS one · 2012Article
- Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.Cytokine · 2011Review
- Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Cell stem cell · 2010Review
- Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming.Leukemia · 2008Review
- Polycomb group genes: keeping stem cell activity in balance.PLoS biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The mouse Polycomb-group gene, embryonic ectoderm development (eed), appears to regulate cellular growth and differentiation in a developmental and tissue specific manner. During embryogenesis, eed regulates axial patterning, whereas in the adult eed represses proliferation of myeloid and B cell precursors. The present report demonstrates two novel functional activities of eed: alteration of thymocyte maturation and suppression of thymic lymphoma development. Mice that inherit the viable hypomorphic 17Rn5(1989SB) eed allele sustain a partial developmental block at or before the CD4(-)CD8(-)CD44(-)CD25(+) stage of thymocyte differentiation. Furthermore, mice that are homozygous or heterozygous for the hypomorphic eed allele have an increased incidence and decreased latency of N-methyl-N-nitrosourea-induced thymic lymphoma compared to wild-type littermates. These findings support the notion that Polycomb-group genes exert pleiotropic effects dictated by developmental stage and cellular context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.