SynthesisMolecular psychiatry2002
Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7.
Synthesis in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Genome-Wide Linkage Study Meta-Analysis of Male Sexual Orientation.Archives of sexual behavior · 2021Pooled it
- Pooled it
- Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease.BMC genetics · 2007Pooled it
- Meta-analysis of genome-wide linkage studies for bone mineral density.Journal of human genetics · 2006Pooled it
- Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches.Journal of human genetics · 2006Pooled it
- A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.Molecular psychiatry · 2006Pooled it
- Meta-analysis in psychiatric genetics.Current psychiatry reports · 2005Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Antioxidant Behavioural Phenotype in theGenes · 2023Article
- Maternal exposure to prostaglandin EBiochemistry and biophysics reports · 2018Article
- Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population.Journal of Zhejiang University. Science. B · 2014Article
- An eQTL mapping approach reveals that rare variants in the SEMA5A regulatory network impact autism risk.Human molecular genetics · 2013Article
- Mutations in the TSGA14 gene in families with autism spectrum disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.Molecular psychiatry · 2010Article
- Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.Biological psychiatry · 2010Article
- Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds.The Journal of comparative neurology · 2010Article
- Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.Molecular autism · 2010Article
- A linkage search for joint panic disorder/bipolar genes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- MET and autism susceptibility: family and case-control studies.European journal of human genetics : EJHG · 2009Article
- Data integration in genetics and genomics: methods and challenges.Human genomics and proteomics : HGP · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the concept of meta-analysis of multiple linkage scans of a genetic trait is not new, it can be difficult to apply to published data given the lack of consistency in the presentation of linkage results. In complex inheritance common diseases, there are many instances where one or two studies meet genome-wide criteria for significant or suggestive linkage but several other studies do not show even nominally significant results with the same region. One possibility for resolving differences between study results would be to combine an available result parameter of several studies. We describe here a method of regional meta-analysis, the multiple-scan probability (MSP), which can be used on published results. It combines the reported P-values of individual studies, after correcting each value for the size of the region containing a minimum P-value. Analyses of the power of MSP and of its type I error rates are presented. The type I error rate is at least as low as that for a single genome scan and thus genome-wide significance criteria may be applied. We also demonstrate appropriate criteria for this type of meta-analysis when the most significant study is included, and when that study is used to define a region of interest and then excluded. In our simulations, meta-analysis is at least as powerful as pooling data. Finally, we apply this method of meta-analysis to the evidence for linkage of autism susceptibility loci and demonstrate evidence for a susceptibility locus at 7q.
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