ArticleThe Biochemical journal2002
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 114 citations in OpenAlex.
- Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways.Cells · 2026Review
- Tankyrase: a promising therapeutic target with pleiotropic action.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Functions of ADP-ribose transferases in the maintenance of telomere integrity.Cellular and molecular life sciences : CMLS · 2022Review
- Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle.Frontiers in endocrinology · 2022Review
- Tankyrase inhibitors hinderParasitology · 2021Article
- Review
- Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.Developmental cell · 2020Article
- Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity.Cellular and molecular life sciences : CMLS · 2020Review
- Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation.Nature communications · 2019Article
- Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase.The Journal of biological chemistry · 2019Article
- RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.Cancer science · 2018Article
- Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.Protein science : a publication of the Protein Society · 2018Article
- 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.Scientific reports · 2018Article
- Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.Nucleic acids research · 2017Article
- Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.Journal of the American Chemical Society · 2017Article
- Structural insights into SAM domain-mediated tankyrase oligomerization.Protein science : a publication of the Protein Society · 2016Article
- The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.Development (Cambridge, England) · 2016Article
- Wnt pathway activation by ADP-ribosylation.Nature communications · 2016Article
- Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The poly(ADP-ribose) polymerase (PARP) tankyrase-1 contains an ankyrin-repeat domain that binds to various partners, including the telomeric protein TRF1 (telomere-repeat-binding factor 1) and the vesicular protein IRAP (insulin-responsive aminopeptidase). TRF1 binding recruits tankyrase-1 to telomeres and allows its PARP activity to regulate telomere homoeostasis. By contrast, IRAP binding and the Golgi co-localization of tankyrase-1 with IRAP might allow tankyrase-1 to affect the targeting of IRAP-containing vesicles. A closely related protein, tankyrase-2, has also been implicated in vesicular targeting. Unlike tankyrase-1, tankyrase-2 has not been shown to have PARP activity. In addition, it has not been implicated in telomere homoeostasis, because it did not interact with TRF1 in previous studies. Here we show that tankyrase-2 contains intrinsic PARP activity and, like tankryase-1, binds to both TRF1 and IRAP. Our analysis suggests that the ankyrin (ANK) domain of tankyrase-2 comprises five subdomains that provide redundant binding sites for IRAP. Moreover, tankyrase-2 associates and co-localizes with tankyrase-1, suggesting that both tankyrases might function as a complex. Taken together, our findings indicate that tankyrase-1 and tankyrase-2 interact with the same set of proteins and probably mediate overlapping functions, both at telomeres and in vesicular compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.