ArticleJournal of virology2002
Phylogenetic analysis of varicella-zoster virus: evidence of intercontinental spread of genotypes and recombination.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Genomic insights of first varicella zoster clade9 strain: a potential silent surge in Pakistan.Virus genes · 2026Article
- Article
- Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China.Virology journal · 2025Article
- Article
- Preliminary investigation and analysis of nucleotide site variability of nine glycoproteins on varicella-zoster virus envelope, Jilin Province, China, 2010-March 2024.Scientific reports · 2024Article
- Whole-Genome Sequence Analysis of Pseudorabies Virus Clinical Isolates from Pigs in China between 2012 and 2017 in China.Viruses · 2021Article
- Molecular characterization of varicella zoster virus isolated from clinical samples in India.The Indian journal of medical research · 2021Article
- Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion.Pathogens (Basel, Switzerland) · 2019Review
- Genotypes of clinical varicella-zoster virus isolates from Manaus, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2019Article
- Article
- Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms.Epidemiology and infection · 2017Article
- Genetic analysis of varicella-zoster virus in the aqueous humor in uveitis with severe hyphema.BMC infectious diseases · 2017Article
- Nationwide distribution of varicella-zoster virus clades in China.BMC infectious diseases · 2016Article
- Epidemic cycling in a multi-strain SIRS epidemic network model.Theoretical biology & medical modelling · 2016Article
- Genotyping of clinical varicella-zoster virus isolates collected from Yunnan in Southwestern China.Biomedical reports · 2016Article
- Enzymatic Digestion Pattern of Varicella Zoster Virus ORF38 and ORF54 in Chickenpox Patients Using RFLP Technique.Iranian journal of pathology · 2016Article
- Genetic Diversity within Alphaherpesviruses: Characterization of a Novel Variant of Herpes Simplex Virus 2.Journal of virology · 2015Article
- Recombination of Globally Circulating Varicella-Zoster Virus.Journal of virology · 2015Article
- Rates of vaccine evolution show strong effects of latency: implications for varicella zoster virus epidemiology.Molecular biology and evolution · 2015Article
- Varicella-zoster.Handbook of clinical neurology · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A heteroduplex mobility assay was used to identify variants of varicella-zoster virus circulating in the United Kingdom and elsewhere. Within the United Kingdom, 58 segregating sites were found out of the 23,266 examined (0.25%), and nucleotide diversity was estimated to be 0.00063. These are an order of magnitude smaller than comparable estimates from herpes simplex virus type 1. Sixteen substitutions were nonsynonymous, the majority of which were clustered within surface-expressed proteins. Extensive genetic correlation between widely spaced sites indicated that recombination has been rare. Phylogenetic analysis of varicella-zoster viruses from four continents distinguished at least three major genetic clades. Most geographical regions contained only one of these three strains, apart from the United Kingdom and Brazil, where two or more strains were found. There was minimal genetic differentiation (one or fewer substitutions in 1,895 bases surveyed) between the samples collected from Africa (Guinea Bissau, Zambia) and the Indian subcontinent (Bangladesh, South India), suggesting recent rapid spread and/or low mutation rates. The geographic pattern of strain distribution would favor a major influence of the former. The genetic uniformity of most virus populations makes recombination difficult to detect. However, at least one probable recombinant between two of the major strains was found among the samples originating from Brazil, where mixtures of genotypes co-occur.
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