ArticleJournal of virology2002
The initiator element in a herpes simplex virus type 1 late-gene promoter enhances activation by ICP4, resulting in abundant late-gene expression.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- ATRX Promotes Transcription Initiation of HSV-1 Immediate Early Genes During Early Lytic Infection.Viruses · 2025Article
- A Revision of Herpes Simplex Virus Type 1 Transcription: First, Repress; Then, Express.Microorganisms · 2024Review
- Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses.Seminars in cell & developmental biology · 2023Review
- Immediate Early Proteins of Herpes Simplex Virus Transiently Repress Viral Transcription before Subsequent Activation.Journal of virology · 2022Article
- The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction.Frontiers in cell and developmental biology · 2022Review
- Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.PLoS pathogens · 2020Article
- Genome replication affects transcription factor binding mediating the cascade of herpes simplex virus transcription.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- An Epstein-Barr Virus-Encoded Protein Complex Requires an Origin of Lytic Replication In Cis to Mediate Late Gene Transcription.PLoS pathogens · 2016Article
- Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.PLoS pathogens · 2014Article
- Transcription of the herpes simplex virus 1 genome during productive and quiescent infection of neuronal and nonneuronal cells.Journal of virology · 2014Article
- The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.Journal of virology · 2012Article
- Improper tagging of the non-essential small capsid protein VP26 impairs nuclear capsid egress of herpes simplex virus.PloS one · 2012Article
- Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells.Journal of virology · 2011Article
- The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts.Journal of virology · 2011Article
- ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.Journal of virology · 2009Article
- Stabilized binding of TBP to the TATA box of herpes simplex virus type 1 early (tk) and late (gC) promoters by TFIIA and ICP4.Journal of virology · 2008Article
- Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells.Journal of virology · 2008Article
- DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4.Journal of virology · 2007Article
- In silico identification of putative promoter motifs of White Spot Syndrome Virus.BMC bioinformatics · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The start site regions of late genes of herpes simplex virus type 1 are similar to the eukaryotic initiator sequence (Inr), have been shown to affect the levels of expression, and may also play a role in transcription activation by the viral activator ICP4. A series of linker-scanning mutations spanning the start site of transcription and several downstream mutations in the true late gC promoter were analyzed in reconstituted in vitro transcription reactions with and without ICP4, as well as in the context of the viral genome during infection. The nucleotide contacts previously found to be important for Inr function were also found to be important for optimal induction by ICP4. While the Inr had a substantial effect on the accumulation of gC RNA during infection, no other sequence downstream of the TATA box to +124 had a significant effect on levels of expression during infection. Therefore, these studies suggest that TATA box and the Inr are the only cis-acting elements required to achieve optimal expression of gC, and that the high levels of late-gene transcription may be largely due to the induction by ICP4, functioning through the Inr element.
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