ArticleGenes & development2002
Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 118 citations in OpenAlex.
- The Drosophila epidermal growth factor receptor pathway regulates Hedgehog signalling and cytoneme behaviour.Nature communications · 2025Article
- An image-based RNAi screen identifies the EGFR signaling pathway as a regulator of Imp RNP granules.Journal of cell science · 2024Article
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development.eLife · 2022Article
- Long Non-Coding RNAInsects · 2022Article
- Escort cell encapsulation ofBiology open · 2019Article
- EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.Nature communications · 2017Article
- Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Cancers · 2017Review
- Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain.Open biology · 2016Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.Genetics · 2014Article
- Endocytosis and signaling during development.Cold Spring Harbor perspectives in biology · 2014Article
- The development and functions of oenocytes.Annual review of entomology · 2014Review
- RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells.TheScientificWorldJournal · 2014Article
- Cytoplasmic capes are nuclear envelope intrusions that are enriched in endosomal proteins and depend upon βH-spectrin and Annexin B9.PloS one · 2014Article
- Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.Journal of cell science · 2013Article
- Signaling mechanisms controlling cell fate and embryonic patterning.Cold Spring Harbor perspectives in biology · 2012Review
- Drosophila Hox and sex-determination genes control segment elimination through EGFR and extramacrochetae activity.PLoS genetics · 2012Article
- Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spitz (Spi) is a TGFalpha homolog that is a cardinal ligand for the Drosophila EGF receptor throughout development. Cleavage of the ubiquitously expressed transmembrane form of Spi (mSpi) precedes EGF receptor activation. We show that the Star and Rhomboid (Rho) proteins are necessary for Spi cleavage in Drosophila cells. Complexes between the Spi and Star proteins, as well as between the Star and Rho proteins were identified, but no Spi-Star-Rho triple complex was detected. This observation suggests a sequential activity of Star and Rho in mSpi processing. The interactions between Spi and Star regulate the intracellular trafficking of Spi. The Spi precursor is retained in the periphery of the nucleus. Coexpression of Star promotes translocation of Spi to a compartment where Rho is present both in cells and in embryos. A Star deletion construct that maintains binding to Spi and Rho, but is unable to facilitate Spi translocation, lost biological activity. These results underscore the importance of regulated intracellular trafficking in processing of a TGFalpha family ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.