ArticleInfection and immunity2002
Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB.Journal of bacteriology · 2022Article
- In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae.Immunological reviews · 2021Review
- Insights intoProteomes · 2021Review
- Analysis of antigens of Mycobacterium leprae by interaction to sera IgG, IgM, and IgA response to improve diagnosis of leprosy.BioMed research international · 2014Review
- Function and Potentials of M. tuberculosis Epitopes.Frontiers in immunology · 2014Review
- Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.Clinical and vaccine immunology : CVI · 2013Article
- Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.Clinical and vaccine immunology : CVI · 2008Article
- An analysis of the epitope knowledge related to Mycobacteria.Immunome research · 2007Article
- The continuing challenges of leprosy.Clinical microbiology reviews · 2006Review
- Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.Infection and immunity · 2005Article
- A second-generation anti TB vaccine is long overdue.Annals of clinical microbiology and antimicrobials · 2004Article
- Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.Infection and immunity · 2004Article
- Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults.Clinical and diagnostic laboratory immunology · 2003Article
- T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients.Infection and immunity · 2002Article
- Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.Infection and immunity · 2002Article
- Proteome analysis of the plasma membrane of Mycobacterium tuberculosis.Comparative and functional genomics · 2002Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.