ArticleInfection and immunity2002
Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Candida albicans CHK1 gene from two-component system is essential for its pathogenicity in oral candidiasis.Applied microbiology and biotechnology · 2021Article
- Article
- Tracing the origin and evolution of pseudokinases across the tree of life.Science signaling · 2019Article
- Crystal Structure of Histidine Triad Nucleotide-Binding Protein from the Pathogenic FungusMolecules and cells · 2019Article
- Stress-Activated Protein Kinases in Human Fungal Pathogens.Frontiers in cellular and infection microbiology · 2019Review
- Identification of Streptococcus mitis321A vaccine antigens based on reverse vaccinology.Molecular medicine reports · 2018Article
- The yeasts phosphorelay systems: a comparative view.World journal of microbiology & biotechnology · 2017Review
- A case for two-component signaling systems as antifungal drug targets.PLoS pathogens · 2015Article
- Genome sequence and virulence variation-related transcriptome profiles of Curvularia lunata, an important maize pathogenic fungus.BMC genomics · 2014Article
- Two-component histidine phosphotransfer protein Ypd1 is not essential for viability in Candida albicans.Eukaryotic cell · 2014Article
- The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research.Disease markers · 2014Review
- Mitochondrial two-component signaling systems in Candida albicans.Eukaryotic cell · 2013Article
- The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.Fungal genetics and biology : FG & B · 2009Article
- Two-component signal transduction proteins as potential drug targets in medically important fungi.Infection and immunity · 2008Review
- A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.Molecular biology of the cell · 2007Article
- Analysis of the dermatophyte Trichophyton rubrum expressed sequence tags.BMC genomics · 2006Article
- Candida albicans killing by RAW 264.7 mouse macrophage cells: effects of Candida genotype, infection ratios, and gamma interferon treatment.Infection and immunity · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.