ArticleInfection and immunity2002
Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 175 citations in OpenAlex.
- Systemic endotoxin levels in chronic indolent periodontal infections.Journal of periodontal research · 2010Trial
- The mechanism of R2ab-mediated attachment to polystyrene surfaces in Staphylococcus epidermidis.The Journal of biological chemistry · 2026Article
- Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model.Scientific reports · 2025Article
- Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Type I Lipoteichoic Acid (LTA) Detection by Western Blot.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Muramyl dipeptide potentiatesFrontiers in immunology · 2024Article
- Type I Lipoteichoic Acid (LTA) Purification by Hydrophobic Interaction Chromatography and Structural Analysis by 2D Nuclear Magnetic Resonance (NMR) Spectroscopy.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition.Cell death discovery · 2023Article
- Human monoclonal antibodies againsteLife · 2022Article
- Effects of lipoteichoic and arachidonic acids on the immune-regulatory mechanism of bovine mammary epithelial cells using multi-omics analysis.Frontiers in veterinary science · 2022Article
- Generation of glucosylatedRSC chemical biology · 2021Article
- GtcA is required for LTA glycosylation inCell surface (Amsterdam, Netherlands) · 2020Article
- Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.Clinical oral investigations · 2020Article
- Hydrophobic ligands influence the structure, stability, and processing of the major cockroach allergen Bla g 1.Scientific reports · 2019Article
- Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion.PLoS pathogens · 2019Article
- Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation.The Journal of biological chemistry · 2018Article
- Staphylococcal LTA antagonizes the B cell-mitogenic potential of LPS.Scientific reports · 2018Article
- Identification of a Lipoteichoic Acid Glycosyltransferase Enzyme Reveals that GW-Domain-Containing Proteins Can Be Retained in the Cell Wall of Listeria monocytogenes in the Absence of Lipoteichoic Acid or Its Modifications.Journal of bacteriology · 2016Article
- Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria.Bioscience of microbiota, food and health · 2016Review
- Characterization of lipoteichoic acid structures from three probiotic Bacillus strains: involvement of D-alanine in their biological activity.Antonie van Leeuwenhoek · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fractionation of commercial preparations of lipoteichoic acids (LTA) by hydrophobic interaction chromatography (HIC) and nuclear magnetic resonance spectroscopy revealed very inhomogeneous compositions and decomposition of the LTA structure: LTA content of the preparations averaged 61% for Streptococcus pyogenes, 16% for Bacillus subtilis, and 75% for Staphylococcus aureus. The decomposition was characterized by a loss of glycerophosphate units as well as alanine and N-acetylglucosamine substituents. All preparations contained-to varying degrees-non-LTA, non-lipopolysaccharide (LPS) immunostimulatory components as indicated by their elution profile in HIC, lack of phosphate, and negative Limulus amoebocyte lysate (LAL) test results. After purification, the commercial LTA from Bacillus subtilis and S. pyogenes but not LTA from S. aureus induced the release of tumor necrosis factor alpha, interleukin 1 beta (IL-1beta), IL-6, and IL-10 in human blood. While pure LTA are negative in the LAL assay, endotoxin equivalents of more than 10 ng of LPS/mg of LTA were found in the commercial preparations. Taken together, these data indicate that these crude preparations with relatively high endotoxin contamination are not suitable for characterizing the activation of immune cells by LTA.
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