ArticleInfection and immunity2002
Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 103 citations in OpenAlex.
- Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci.F1000Research · 2026Review
- Hydrodynamic Size Modulation of Exopolysaccharides fromJournal of microbiology and biotechnology · 2025Article
- Molecular Targets inGenes · 2024Review
- Streptococcal peptides and their roles in host-microbe interactions.Frontiers in cellular and infection microbiology · 2023Review
- Article
- Functional and Proteomic Analysis ofFrontiers in microbiology · 2019Article
- Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis.Scientific reports · 2018Article
- Article
- Repression of Rgg But Not Upregulation of LacD.1 inFrontiers in microbiology · 2016Article
- Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme.Molecular microbiology · 2015Article
- Mechanisms of group A Streptococcus resistance to reactive oxygen species.FEMS microbiology reviews · 2015Review
- Rgg protein structure-function and inhibition by cyclic peptide compounds.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents.Bioorganic & medicinal chemistry letters · 2014Article
- Quorum sensing in group A Streptococcus.Frontiers in cellular and infection microbiology · 2014Review
- Enterococcal Rgg-like regulator ElrR activates expression of the elrA operon.Journal of bacteriology · 2013Article
- Article
- Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.Journal of bacteriology · 2012Article
- The rgg0182 gene encodes a transcriptional regulator required for the full Streptococcus thermophilus LMG18311 thermal adaptation.BMC microbiology · 2011Article
- Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development.PLoS pathogens · 2011Article
- Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.The Journal of clinical investigation · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The human pathogen Streptococcus pyogenes secretes many proteins to the cell wall and extracellular environment that contribute to virulence. Rgg regulates the expression of several exoproteins including a cysteine protease (SPE B), a nuclease (MF-1), a putative nuclease (MF-3), and autolysin. The functional heterogeneity of Rgg-regulated exoproteins and the lack of a conserved regulatory motif in the promoter regions of the genes suggested that Rgg interacts with additional regulatory networks to influence gene expression. DNA microarrays were used to test this hypothesis by comparing genomewide transcript profiles of S. pyogenes NZ131 and isogenic derivative NZ131 rgg during the exponential phase of growth. Transcripts of known and putative virulence-associated genes were more abundant in the rgg mutant, including emm, scpA, orfX, scl1, hasAB, slo, sagA, ska, speH, grab, mac, mf-1, and mf-3. Increased transcription of emm, scpA, and orfX in the rgg mutant was associated with increased production of the corresponding proteins. Differences in the expression of virulence-associated genes were associated with changes in the expression of several regulatory genes, including mga, sagA, csrRS, and fasBCA. The results show that Rgg influences the expression of multiple regulatory networks to coregulate virulence factor expression in S. pyogenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.