ArticleInfection and immunity2002
Primary role for CD4(+) T lymphocytes in recovery from oropharyngeal candidiasis.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 78 citations in OpenAlex.
- Divergent EGFR/MAPK-Mediated Immune Responses to ClinicalFrontiers in immunology · 2022Article
- Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020Review
- Article
- Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework.Infection and immunity · 2016Review
- Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.The Journal of experimental medicine · 2014Article
- Fungal morphogenetic pathways are required for the hallmark inflammatory response during Candida albicans vaginitis.Infection and immunity · 2014Article
- Review
- Mouse model of oropharyngeal candidiasis.Nature protocols · 2012Article
- Hosting infection: experimental models to assay Candida virulence.International journal of microbiology · 2012Article
- New approaches in the development of a vaccine for mucosal candidiasis: progress and challenges.Frontiers in microbiology · 2012Article
- The effect of the expression of virulence-associated DEAD-box RNA helicase mRNA on the imbalance of Th1-Th2 cytokines in the CSF of patients with Cryptococcus neoformans meningitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Detection of a new embryonic antigen (ESA-10) in the blood of patients with cancer: preliminary results in the United States.Medical oncology (Northwood, London, England) · 2011Article
- IL-12 and related cytokines: function and regulatory implications in Candida albicans infection.Clinical & developmental immunology · 2011Review
- Th17 cytokines in mucosal immunity and inflammation.Current opinion in HIV and AIDS · 2010Review
- Yeasts in the gut: from commensals to infectious agents.Deutsches Arzteblatt international · 2009Review
- Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.Infection and immunity · 2009Article
- Rethinking T cell immunity in oropharyngeal candidiasis.The Journal of experimental medicine · 2009Article
- Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis.Expert reviews in molecular medicine · 2008Review
- Animal models of mucosal Candida infection.FEMS microbiology letters · 2008Review
- Self-regulation of Candida albicans population size during GI colonization.PLoS pathogens · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oropharyngeal candidiasis is associated with defects in cell-mediated immunity and is commonly seen in human immunodeficiency virus positive individuals and AIDS patients. A model for oral candidiasis in T-cell-deficient BALB/c and CBA/CaH nu/nu mice was established. After inoculation with 10(8) Candida albicans yeasts, these mice displayed increased levels of oral colonization compared to euthymic control mice and developed a chronic oropharyngeal infection. Histopathological examination of nu/nu oral tissues revealed extensive hyphae penetrating the epithelium, with polymorphonuclear leukocyte microabscess formation. Adoptive transfer of either naive or immune lymphocytes into immunodeficient mice resulted in the recovery of these animals from the oral infection. Reconstitution of immunodeficient mice with naive CD4(+) but not CD8(+) T cells significantly decreased oral colonization compared to controls. Interleukin-12 and gamma interferon were detected in the draining lymph nodes of immunodeficient mice following reconstitution with naive lymphocytes. This study demonstrates the direct requirement for T lymphocytes in recovery from oral candidiasis and suggests that this is associated with the production of cytokines by CD4(+) T helper cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.