ReviewHeart (British Cardiac Society)2002
Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies.
Review in Heart (British Cardiac Society), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis.Medicine · 2018Pooled it
- Associations between interleukin-1 gene polymorphisms and coronary heart disease risk: a meta-analysis.PloS one · 2012Pooled it
- A Genetic Risk Score for Recurrent Miscarriages Based on Polymorphisms in Platelet Glycoproteins and Adhesion Molecules Genes.Journal of clinical medicine · 2025Article
- Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease.International journal of molecular sciences · 2023Review
- Article
- Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease.Cardiovascular therapeutics · 2022Article
- Inflammation and cardiovascular disease: From mechanisms to therapeutics.American journal of preventive cardiology · 2020Review
- Editorial commentary: Are cytokines ready for prime time? Insights from markers and trials.Trends in cardiovascular medicine · 2018Article
- Detection of atherosclerotic plaques in ApoE-deficient mice using (99m)Tc-duramycin.Nuclear medicine and biology · 2016Article
- Association of transforming growth factor-β1 gene C509T, G800A and T869C polymorphisms with intracerebral hemorrhage in North Indian Population: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Ultrasound Biomicroscopic Imaging for Interleukin-1 Receptor Antagonist-Inhibiting Atherosclerosis and Markers of Inflammation in Atherosclerotic Development in Apolipoprotein-E Knockout Mice.Texas Heart Institute journal · 2015Article
- Association of rs5368 and rs3917406 polymorphisms in E-selectin gene with premature coronary artery disease in Chinese Han population.International journal of clinical and experimental medicine · 2015Article
- Ascending thoracic aortic aneurysms protect against myocardial infarctions.The International journal of angiology : official publication of the International College of Angiology, Inc · 2014Article
- Reduction of adhesion molecule production and alteration of eNOS and endothelin-1 mRNA expression in endothelium by Euphorbia hirta L. through its beneficial β-amyrin molecule.Molecules (Basel, Switzerland) · 2014Article
- Targeting interleukin-1 in heart disease.Circulation · 2013Review
- Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age.Journal of epidemiology · 2013Article
- Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population.Gastroenterology research and practice · 2013Article
- Doinseunggitang ameliorates endothelial dysfunction in diabetic atherosclerosis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level.BMC medical genetics · 2012Article
- Arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/cholesterol diets.BMC complementary and alternative medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation and genetics are both prominent mechanisms in the pathogenesis of atherosclerosis and arterial thrombosis. Accordingly, a number of population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules tumour necrosis factors (TNF) alpha and beta, transforming growth factors (TGF) beta1 and 2, interleukin (IL) 1 and its receptor antagonist (IL 1ra), CD14 (the receptor for lipopolysaccharide), P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Although they are very preliminary and partly conflicting, the data provide some evidence that alterations in the genetics of the inflammatory system may modify the risk of ischaemic heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.