ArticleAntimicrobial agents and chemotherapy2002
Expression of lux genes in a clinical isolate of Streptococcus pneumoniae: using bioluminescence to monitor gemifloxacin activity.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- RNAIII is linked with the pentose phosphate pathway through the activation of RpiRc inmSphere · 2024Article
- Bioluminescent Models to Evaluate the Efficiency of Light-Based Antibacterial Approaches.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Construction and evaluation of a bioluminescentMicrobiology (Reading, England) · 2021Article
- Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis.Scientific reports · 2017Article
- An in vivo reporter assay for sRNA-directed gene control in Gram-positive bacteria: identifying a novel sRNA target in Staphylococcus aureus.Nucleic acids research · 2017Article
- Electricity and disinfectant production from wastewater: Microbial Fuel Cell as a self-powered electrolyser.Scientific reports · 2016Article
- Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression.Frontiers in microbiology · 2016Article
- A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease.BMC genomics · 2014Article
- Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth.Journal of the Royal Society, Interface · 2013Article
- Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.PloS one · 2013Article
- CovR alleviates transcriptional silencing by a nucleoid-associated histone-like protein in Streptococcus mutans.Journal of bacteriology · 2012Article
- Application of bacterial bioluminescence to assess the efficacy of fast-acting biocides.Antimicrobial agents and chemotherapy · 2011Article
- LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae.Infection and immunity · 2011Article
- In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals.Sensors (Basel, Switzerland) · 2011Review
- Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumoniae serotypes.Antimicrobial agents and chemotherapy · 2010Article
- Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae.Antimicrobial agents and chemotherapy · 2010Article
- Antimicrobial photodynamic therapy: study of bacterial recovery viability and potential development of resistance after treatment.Marine drugs · 2010Article
- In vivo bioluminescence imaging for the study of intestinal colonization by Escherichia coli in mice.Applied and environmental microbiology · 2010Article
- Photodynamic inactivation of recombinant bioluminescent Escherichia coli by cationic porphyrins under artificial and solar irradiation.Journal of industrial microbiology & biotechnology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A clinical isolate of Streptococcus pneumoniae was transformed with a plasmid containing the lux operon of Photorhabdus luminescens that had been modified to function in gram-positive bacteria. Cells containing this plasmid produced light stably and constitutively, without compromising the growth rate. Light output was correlated with measurements of optical density and viable counts during exponential growth and provided a sensitive, real-time measure of the pharmacodynamics of the fluoroquinolone gemifloxacin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.