ArticleAntimicrobial agents and chemotherapy2002
Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbits.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- Successful Salvage of Central Venous Catheters in Patients with Catheter-Related or Central Line-Associated Bloodstream Infections by Using a Catheter Lock Solution Consisting of Minocycline, EDTA, and 25% Ethanol.Antimicrobial agents and chemotherapy · 2016Trial
- Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis.Journal of the American Society of Nephrology : JASN · 2011Trial
- Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Review
- Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (International ed. in English) · 2022Review
- Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms.Frontiers in microbiology · 2020Review
- The biofilm matrix destabilizers, EDTA and DNaseI, enhance the susceptibility of nontypeable Hemophilus influenzae biofilms to treatment with ampicillin and ciprofloxacin.MicrobiologyOpen · 2014Article
- Antibiotic lock therapy: review of technique and logistical challenges.Infection and drug resistance · 2014Review
- From in vitro to in vivo Models of Bacterial Biofilm-Related Infections.Pathogens (Basel, Switzerland) · 2013Review
- In situ crosslinkable heparin-containing poly(ethylene glycol) hydrogels for sustained anticoagulant release.Journal of biomedical materials research. Part A · 2012Article
- Miracle molecules of our age: ethylenediaminetetraacetic acid.Science progress · 2011Article
- Clinical outcomes of antimicrobial lock solutions used in a treatment modality: a retrospective case series analysis.Clinical pharmacology : advances and applications · 2010Article
- The effect of EDTA instillations on the rate of development of encrustation and biofilms in Foley catheters.Urological research · 2009Article
- Noninvasive ventilation for patients near the end of life: what do we know and what do we need to know?Critical care medicine · 2008Article
- Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm.Antimicrobial agents and chemotherapy · 2007Article
- Comparative in vitro efficacies of various catheter lock solutions.Antimicrobial agents and chemotherapy · 2006Article
- Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm.Applied and environmental microbiology · 2006Article
- Vancomycin-resistant Enterococcus faecium: catheter colonization, esp gene, and decreased susceptibility to antibiotics in biofilm.Antimicrobial agents and chemotherapy · 2005Article
- Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro.Journal of clinical microbiology · 2004Article
- Lysostaphin-coated catheters eradicate Staphylococccus aureus challenge and block surface colonization.Antimicrobial agents and chemotherapy · 2004Article
- In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces.Antimicrobial agents and chemotherapy · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the efficacy of antibiotic catheter lock solution in preventing catheter-related infections, silicone catheters were tunneled and inserted into the jugular veins of 18 rabbits. The catheters were challenged with an intraluminal injection of 10(5) CFU of slime-producing Staphylococcus epidermidis in 0.1 ml of water. The catheters were maintained on heparin (100 IU/ml) flush for the first 3 days. On day 3, quantitative blood samples for culture were obtained from the catheters and ear veins, which documented catheter-related bacteremia, and the rabbits were randomized to have their catheters flushed as follows: five animals were continued on heparin (100 IU/ml), five animals received vancomycin (3 mg/ml) with heparin (100 IU/ml), and eight animals received 3 mg of minocycline per ml with 30 mg of EDTA per ml (M-EDTA). All animals were killed at day 7. Blood, catheters, jugular veins, and heart valves were cultured quantitatively. Animals maintained on heparin developed catheter-related colonization, bacteremia, septic phlebitis, and endocarditis. Vancomycin-heparin partially prevented catheter colonization, bacteremia, and phlebitis (P = 0.2). M-EDTA completely prevented catheter colonization, catheter-related bacteremia, and phlebitis in all of the animals (P < 0.01). Tricuspid endocarditis was equally prevented by vancomycin-heparin and M-EDTA (P < or = 0.06). In conclusion, the M-EDTA catheter flush solution was highly efficacious in preventing catheter-related colonization, bacteremia, septic phlebitis, and endocarditis in rabbits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.