ArticleProceedings of the National Academy of Sciences of the United States of America2002
Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3-Mediated Indian Hedgehog Signaling.The American journal of pathology · 2018Article
- Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes.International journal of molecular sciences · 2018Article
- Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation.The American journal of pathology · 2017Article
- Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.EMBO molecular medicine · 2011Article
- Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.BMC genomics · 2005Article
- N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.Microbiology and molecular biology reviews : MMBR · 2005Review
- X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- MuTrack: a genome analysis system for large-scale mutagenesis in the mouse.BMC bioinformatics · 2004Review
- Overlapping deletions spanning the proximal two-thirds of the mouse t complex.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Eleven independent, recessive, N-ethyl-N-nitrosourea-induced mutations that map to a approximately 1- to 2-cM region of mouse chromosome (Chr) 7 homologous to human Chr 11p14-p15 were recovered from a screen of 1,218 gametes. These mutations were initially identified in a hemizygous state opposite a large p-locus deletion and subsequently were mapped to finer genomic intervals by crosses to a panel of smaller p deletions. The 11 mutations also were classified into seven complementation groups by pairwise crosses. Four complementation groups were defined by seven prenatally lethal mutations, including a group (l7R3) comprised of two alleles of obvious differing severity. Two allelic mutations (at the psrt locus) result in a severe seizure and runting syndrome, but one mutation (at the fit2 locus) results in a more benign runting phenotype. This experiment has added seven loci, defined by phenotypes of presumed point mutations, to the genetic map of a small (1-2 cM) region of mouse Chr 7 and will facilitate the task of functional annotation of DNA sequence and transcription maps both in the mouse and the corresponding human 11p14-p15 homology region.
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