ArticleProceedings of the National Academy of Sciences of the United States of America2002
Differential role of SLP-76 domains in T cell development and function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- T cell receptor (TCR) signaling in health and disease.Signal transduction and targeted therapy · 2021Review
- Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.The Journal of experimental medicine · 2021Article
- The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt From Inborn Errors of Immunity.Frontiers in immunology · 2021Review
- Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses.Frontiers in immunology · 2019Review
- A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.Journal of proteome research · 2017Article
- Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy.Frontiers in immunology · 2016Review
- Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.European journal of immunology · 2015Article
- Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.PloS one · 2012Article
- The SLP-76 Src homology 2 domain is required for T cell development and activation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.European journal of immunology · 2011Article
- Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.Science signaling · 2011Article
- Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.BMC immunology · 2011Article
- Understanding signal integration through targeted mutations of an adapter protein.FEBS letters · 2010Article
- Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.Cold Spring Harbor perspectives in biology · 2010Review
- Article
- The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function.Immune network · 2009Article
- WIP is critical for T cell responsiveness to IL-2.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.The Journal of biological chemistry · 2009Article
- Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.The Journal of experimental medicine · 2008Article
- Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.Immunity · 2008Article
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Authors and funding
5 authors.
Funding
Abstract
The adapter SLP-76 is essential for thymocyte development. SLP-76(-/-) mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired transition from double to single positive thymocytes, and decreased numbers of mature T cells in the spleen. Calcium mobilization and extracellular signal-regulated protein kinase activation were decreased in the Gads-binding site mutant but almost normal in the SH2 domain mutant. T cells from both mutants failed to proliferate following T cell antigen receptor ligation. Nevertheless, both mutants mounted partial cutaneous hypersensitivity responses and normal T cell dependent IgG1 antibody responses. These results indicate differential roles for SLP-76 domains in T cell development, proliferation and effector functions.
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