ArticleProceedings of the National Academy of Sciences of the United States of America2002
Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 64 citations in OpenAlex.
- Transcriptomic analysis of resistance and short-term induction response to pyrethroids, in Anopheles coluzzii legs.BMC genomics · 2021Article
- Transcriptional variation of sensory-related genes in natural populations of Aedes albopictus.BMC genomics · 2020Article
- Opsin expression patterns coincide with photoreceptor development during pupal development in the honey bee, Apis mellifera.BMC developmental biology · 2018Article
- Deciphering the olfactory repertoire of the tiger mosquito Aedes albopictus.BMC genomics · 2017Article
- Tick Haller's Organ, a New Paradigm for Arthropod Olfaction: How Ticks Differ from Insects.International journal of molecular sciences · 2017Article
- Transcriptome sequencing and developmental regulation of gene expression in Anopheles aquasalis.PLoS neglected tropical diseases · 2014Article
- Morphological and physiological characteristics of dermal photoreceptors in Lymnaea stagnalis.Biophysics (Nagoya-shi, Japan) · 2014Article
- Article
- Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents.Cellular and molecular life sciences : CMLS · 2012Article
- Potential insight for drug discovery from high fidelity receptor-mediated transduction mechanisms in insects.Expert opinion on drug discovery · 2011Article
- The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila.PloS one · 2011Article
- Arrestin in ciliary invertebrate photoreceptors: molecular identification and functional analysis in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction.Journal of insect physiology · 2008Article
- Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster.BMC genomics · 2007Article
- Type 1 angiotensin receptor pharmacology: signaling beyond G proteins.Pharmacology & therapeutics · 2007Review
- A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity.Chemical senses · 2006Article
- Molecular biology of insect olfaction: recent progress and conceptual models.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Review
- Olfactory regulation of mosquito-host interactions.Insect biochemistry and molecular biology · 2004Review
- A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
Arrestins are important components for desensitization of G protein-coupled receptor cascades that mediate neurotransmission as well as olfactory and visual sensory reception. We have isolated AgArr1, an arrestin-encoding cDNA from the malaria vector mosquito, Anopheles gambiae, where olfaction is critical for vectorial capacity. Analysis of AgArr1 expression revealed an overlap between chemosensory and photoreceptor neurons. Furthermore, an examination of previously identified arrestins from Drosophila melanogaster exposed similar bimodal expression, and Drosophila arrestin mutants demonstrate impaired electrophysiological responses to olfactory stimuli. Thus, we show that arrestins in Drosophila are required for normal olfactory physiology in addition to their previously described role in visual signaling. These findings suggest that individual arrestins function in both olfactory and visual pathways in Dipteran insects; these genes may prove useful in the design of control strategies that target olfactory-dependent behaviors of insect disease vectors.
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