ArticleProceedings of the National Academy of Sciences of the United States of America2002
Supervillin associates with androgen receptor and modulates its transcriptional activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 100 citations in OpenAlex.
- The Microbial Metabolite IDA Sensitizes Tumor Cells to ARF1 Inhibition by Inducing SVIL-dependent Senescence.International journal of biological sciences · 2026Article
- Androgens as the "old age stick" in skeletal muscle.Cell communication and signaling : CCS · 2025Review
- Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer.Cancer medicine · 2025Article
- Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages.Inflammation · 2022Article
- Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells.BioTechniques · 2021Article
- Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles.Brain : a journal of neurology · 2020Article
- An emerging link between LIM domain proteins and nuclear receptors.Cellular and molecular life sciences : CMLS · 2018Review
- Functions of nuclear actin-binding proteins in human cancer.Oncology letters · 2018Article
- Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms.PloS one · 2018Article
- Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.Journal of cell science · 2016Article
- Preparation and Affinity-Purification of Supervillin Isoform 4 (SV4) Specific Polyclonal Antibodies.The protein journal · 2016Article
- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.Experimental & molecular medicine · 2015Article
- Histone demethylases in chromatin biology and beyond.EMBO reports · 2015Review
- A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation.Molecular cell · 2015Article
- Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Sphingosine kinase 1 isoform-specific interactions in breast cancer.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression.Small GTPases · 2014Review
- 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor.International journal of cancer · 2013Article
- Supervillin-mediated suppression of p53 protein enhances cell survival.The Journal of biological chemistry · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of androgen receptor (AR) via androgen in muscle cells has been closely linked to their growth and differentiation. Here, we report the cloning and characterization of supervillin (SV), a 205-kDa actin-binding protein, as an AR coregulator from the skeletal muscle cDNA library. Mammalian two-hybrid and glutathione S-transferase pull-down assays indicate a domain within SV (amino acids 594-1268) can interact with AR N terminus and DNA-binding domain-ligand-binding domain in a ligand-enhanced manner. Subcellular colocalization studies with fluorescence staining indicate SV can colocalize with AR in the presence of 5 alpha-dihydrotestosterone in COS-1 cells. The functional reporter assays showed full-length SV and the SV peptide (amino acids 831-1281) within the interaction domain can enhance AR transactivation. Furthermore, SV can enhance the endogenous AR target gene, p27(KIP1), expression in prostate PC-3(AR2) cells. SV preferentially enhanced AR rather than other tested nuclear receptors and could be induced by natural androgens better than other steroids. SV can also cooperate with other AR coregulators, such as ARA55 or ARA70, to enhance AR transactivation further. Unlike SRC-1 that can enhance the interaction between AR N terminus and AR C terminus, SV shows a mild suppressive effect on N-C interactions, suggesting SV may go through a different mechanism to enhance AR transactivation. Together, our data demonstrate that SV is an AR coregulator that can enhance AR transactivation in muscle and other cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.