ArticleProceedings of the National Academy of Sciences of the United States of America2002
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 92 citations in OpenAlex.
- The Role of Emerin in Cancer Progression and Metastasis.International journal of molecular sciences · 2021Review
- Molecular Trajectory ofFrontiers in oncology · 2020Review
- Article
- BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.Journal of the National Cancer Institute · 2016Article
- African American women's limited knowledge and experiences with genetic counseling for hereditary breast cancer.Journal of genetic counseling · 2014Article
- Article
- Heterozygous mutations in DNA repair genes and hereditary breast cancer: a question of power.PLoS genetics · 2012Article
- Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma.Experimental and therapeutic medicine · 2011Article
- KIAA0101 interacts with BRCA1 and regulates centrosome number.Molecular cancer research : MCR · 2011Article
- Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7.Cancer science · 2009Article
- Genome-wide linkage scan reveals three putative breast-cancer-susceptibility loci.American journal of human genetics · 2009Article
- Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies.BMC genomics · 2007Article
- A genome wide linkage search for breast cancer susceptibility genes.Genes, chromosomes & cancer · 2006Article
- BRCA1 and BRCA2 mutations in breast and ovarian cancer syndrome: reflection on the Creighton University historical series of high risk families.Familial cancer · 2006Review
- Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource.Breast cancer research : BCR · 2006Article
- BAP1 and breast cancer risk.Familial cancer · 2005Article
- The genetic epidemiology of breast cancer genes.Journal of mammary gland biology and neoplasia · 2004Review
- Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.American journal of human genetics · 2003Article
- Molecular classification of familial non-BRCA1/BRCA2 breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
49 authors at 8 institutions in 4 countries.
Funding
Abstract
The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer families from Scandinavia found evidence of linkage between the disease and polymorphic markers on chromosome 13q21. We have evaluated the contribution of this candidate "BRCA3" locus to breast cancer susceptibility in 128 high-risk breast cancer families of Western European ancestry with no identified BRCA1 or BRCA2 mutations. No evidence of linkage was found. The estimated proportion (alpha) of families linked to a susceptibility locus at D13S1308, the location estimated by Kainu et al. [(2000) Proc. Natl. Acad. Sci. USA 97, 9603-9608], was 0 (upper 95% confidence limit 0.13). Adjustment for possible bias due to selection of families on the basis of linkage evidence at BRCA2 did not materially alter this result (alpha = 0, upper 95% confidence limit 0.18). The proportion of linked families reported by Kainu et al. (0.65) is excluded with a high degree of confidence in our dataset [heterogeneity logarithm of odds (HLOD) at alpha = 0.65 was -11.0]. We conclude that, if a susceptibility gene does exist at this locus, it can only account for a small proportion of non-BRCA1/2 families with multiple cases of early-onset breast cancer.
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