ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2002
Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Mitochondrial Bioenergetics and Turnover during Chronic Muscle Disuse.International journal of molecular sciences · 2021Review
- Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice.Experimental gerontology · 2019Article
- Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts.The Journal of nutritional biochemistry · 2017Article
- MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis.Cell death and differentiation · 2016Article
- Regulation of satellite cell function in sarcopenia.Frontiers in aging neuroscience · 2014Review
- Article
- Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.Journal of muscle research and cell motility · 2012Article
- The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.International journal of biological sciences · 2012Review
- Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function.Aging clinical and experimental research · 2011Article
- Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure.Journal of molecular histology · 2011Article
- Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts.PloS one · 2009Article
- Down-regulation of MyoD gene expression in rat diaphragm muscle with heart failure.International journal of experimental pathology · 2008Article
- p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.Molecular biology of the cell · 2008Article
- Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle.International journal of experimental pathology · 2006Article
- Molecular regulation of apoptosis in fast plantaris muscles of aged rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2006Article
- The role of apoptosis in age-related skeletal muscle atrophy.Sports medicine (Auckland, N.Z.) · 2005Review
- Identification of differentially expressed genes in skeletal muscle of non-diabetic insulin-resistant and insulin-sensitive Pima Indians by differential display PCR.Diabetologia · 2003Article
- Exercise-induced expression of vascular endothelial growth factor mRNA in rat skeletal muscle is dependent on fibre type.The Journal of physiology · 2003Article
- Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle.The Journal of physiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The objective of this study was to determine if levels of repressors to myogenic regulatory factors (MRFs) differ between muscles from young adult and aged animals. Total RNA from plantaris, gastrocnemius, and soleus muscles of Fischer 344 x Brown Norway rats aged 9 mo (young adult, n = 10) and 37 mo (aged, n = 10) was reverse transcribed and then amplified by PCR. To obtain a semiquantitative measure of the mRNA levels, PCR signals were normalized to cyclophilin or 18S signals from the corresponding reverse transcription product. Normalization to cyclophilin and 18S gave similar results. The mRNA levels of MyoD and myogenin were approximately 275-650% (P < 0.001) and approximately 500-1,100% (P < 0.001) greater, respectively, in muscles from aged compared with young adults. In contrast, the protein levels were lower in plantaris and gastrocnemius muscles and similar in the soleus muscle of aged vs. young adult rats. Id repressor mRNA levels were approximately 300-900% greater in fast and slow muscles of aged animals (P < or = 0.02), and Mist 1 mRNA was approximately 50% greater in the plantaris and gastrocnemius muscles (P < 0.01). The mRNA level of Twist mRNA was not significantly affected by aging. Id-1, Id-2, and Id-3 protein levels were approximately 17-740% greater (P < 0.05) in hindlimb muscles of aged rats compared with young adult rats. The elevated levels of Id mRNA and protein suggest that MRF repressors may play a role in gene regulation of fast and slow muscles in aged rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.