ArticleAmerican journal of human genetics2002
A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.Genome biology · 2020Article
- A rank-based normalization method with the fully adjusted full-stage procedure in genetic association studies.PloS one · 2020Article
- An adaptive microbiome α-diversity-based association analysis method.Scientific reports · 2018Article
- Are your covariates under control? How normalization can re-introduce covariate effects.European journal of human genetics : EJHG · 2018Article
- Mapping quantitative traits in unselected families: algorithms and examples.Genetic epidemiology · 2009Article
- Rank-based inverse normal transformations are increasingly used, but are they merited?Behavior genetics · 2009Article
- Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.Human biology · 2008Article
- Robust score statistics for QTL linkage analysis.American journal of human genetics · 2008Article
- Controlling for false positive findings of trans-hubs in expression quantitative trait loci mapping.BMC proceedings · 2007Article
- Heritability of cardiovascular and personality traits in 6,148 Sardinians.PLoS genetics · 2006Article
- Quantitative trait linkage analysis using Gaussian copulas.Genetics · 2006Article
- Article
- A powerful and robust method for mapping quantitative trait loci in general pedigrees.American journal of human genetics · 2005Article
- Mapping quantitative trait loci in humans: achievements and limitations.The Journal of clinical investigation · 2005Review
- Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study.BMC genetics · 2003Article
- Genome-wide linkage analysis of blood pressure under locus heterogeneity.BMC genetics · 2003Article
- Linkage analysis of systolic blood pressure: a score statistic and computer implementation.BMC genetics · 2003Article
- Recent advances in human quantitative-trait-locus mapping: comparison of methods for selected sibling pairs.American journal of human genetics · 2003Article
- Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs.American journal of human genetics · 2003Article
- Regression-based quantitative-trait-locus mapping in the 21st century.American journal of human genetics · 2002Article
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2 authors.
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Abstract
The Haseman-Elston method is widely used for the mapping of quantitative-trait loci. However, this method does not use all the information in the data, because it only considers the sib-pair trait-value difference. In addition, the Haseman-Elston method was developed for independent sib pairs; its generalization to nonindependent sib pairs is not straightforward. Here we introduce a score test statistic derived from a normal likelihood based on multiplex sibship data, conditional on identical-by-descent sharing statuses. This score test is asymptotically equivalent to the corresponding likelihood-ratio test, but it is much easier to implement. Because the proposed test uses all of the trait values, it makes more efficient use of the data than does the Haseman-Elston method. The proposed test is naturally applicable to sibships of arbitrary size. The finite-sample properties of the proposed score statistic are evaluated via simulations.
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