ArticleThe Journal of physiology2002
Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanisms.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 96 citations in OpenAlex.
- Is adenosine a modulator of peripheral vasoconstrictor responses?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Trial
- Cutaneous postural vasoconstriction is modified by exogenous but not endogenous female hormones in young women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2007Trial
- Does peripheral nerve degeneration affect circulatory responses to head-up tilt in spinal cord-injured individuals?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2005Trial
- Effect of local heating and vasodilation on the cutaneous venoarteriolar response.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004Trial
- Influence of different cuff inflation protocols on capillary filtration capacity in human calves -- a congestion plethysmography study.The Journal of physiology · 2002Trial
- Ageing attenuates regional vasoconstriction during acute lowering of upper and lower limbs.Experimental physiology · 2026Article
- Evidence of myogenic vasoconstriction in human bone vasculature.Physiological reports · 2025Article
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- Revisiting the Venoarteriolar Reflex-Further Insights from Upper Limb Dependency in Healthy Subjects.Biology · 2024Article
- Spectral changes in skin blood flow during pressure manipulations or sympathetic stimulation.Experimental physiology · 2024Article
- In vivo pressure-flow relation of human cutaneous vessels following prolonged iterative exposures to hypergravity.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Effect of reflex and mechanical decreases in skin perfusion on thermal- and agonist-induced eccrine sweating in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- The acute adaptation of skin microcirculatory perfusionFrontiers in physiology · 2023Article
- Impact of tetraplegia vs. paraplegia on venoarteriolar, myogenic and maximal cutaneous vasodilation responses of the microvasculature: Implications for cardiovascular disease.The journal of spinal cord medicine · 2022Observational
- Canadian Postoperative Dependency Protocols Following Lower Limb Microvascular Reconstruction: A National Survey and Literature Review.Plastic surgery (Oakville, Ont.) · 2021Article
- Mechanisms of Venoarteriolar Reflex in Type 2 Diabetes with or without Peripheral Neuropathy.Biology · 2021Article
- Spatial heterogeneity of cutaneous blood flow respiratory-related oscillations quantified via laser speckle contrast imaging.PloS one · 2021Article
- Current Knowledge on the Vascular Effects of Menthol.Frontiers in physiology · 2020Review
- The autonomic innervation of hairy skin in humans: an in vivo confocal study.Scientific reports · 2019Article
- The Venoarteriolar Reflex Significantly Reduces Contralateral Perfusion as Part of the Lower Limb Circulatory HomeostasisFrontiers in physiology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The venoarteriolar response causes vasoconstriction to skin and muscle via local mechanisms secondary to venous congestion. The purpose of this project was to investigate whether this response occurs through alpha-adrenergic mechanisms. In supine individuals, forearm skin blood flow was monitored via laser-Doppler flowmetry over sites following local administration of terazosin (alpha(1)-antagonist), yohimbine (alpha(2)-antagonist), phentolamine (non-selective alpha-antagonist) and bretylium tosylate (inhibits neurotransmission of adrenergic nerves) via intradermal microdialysis or intradermal injection. In addition, skin blood flow was monitored over an area of forearm skin that was locally anaesthetized via application of EMLA (2.5 % lidocaine (lignocaine) and 2.5 % prilocaine) cream. Skin blood flow was also monitored over adjacent sites that received the vehicle for the specified drug. Each trial was performed on a minimum of seven subjects and on separate days. The venoarteriolar response was engaged by lowering the subject's arm from heart level such that the sites of skin blood flow measurement were 34 +/- 1 cm below the heart. The arm remained in this position for 2 min. Selective and non-selective alpha-adrenoceptor antagonism and presynaptic inhibition of adrenergic neurotransmission did not abolish the venoarteriolar response. However, local anaesthesia blocked the venoarteriolar response without altering alpha-adrenergic mediated vasoconstriction. These data suggest that the venoarteriolar response does not occur through adrenergic mechanisms as previously reported. Rather, the venoarteriolar response may due to myogenic mechanisms associated with changes in vascular pressure or is mediated by a non-adrenergic, but neurally mediated, local mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.