ArticleJournal of bacteriology2002
Galactose and lactose genes from the galactose-positive bacterium Streptococcus salivarius and the phylogenetically related galactose-negative bacterium Streptococcus thermophilus: organization, sequence, transcription, and activity of the gal gene products.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Effect of sugar transporter on galactose utilization inFrontiers in microbiology · 2023Article
- Article
- Nonstarter Bacterial Communities in Aged Cheddar Cheese: Patterns on Two Timescales.Applied and environmental microbiology · 2022Article
- Milk fermentation by monocultures or co-cultures ofFrontiers in bioengineering and biotechnology · 2022Article
- Article
- GlaR (YugA)-a novel RpiR-family transcription activator of the Leloir pathway of galactose utilization in Lactococcus lactis IL1403.MicrobiologyOpen · 2019Article
- β-Galactosidase fromInternational journal of molecular sciences · 2019Article
- Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation.BMC microbiology · 2018Article
- Quantitative Proteomics of Strong and Weak Biofilm Formers ofMolecular & cellular proteomics : MCP · 2018Article
- Comparative Transcriptomic Analysis ofFrontiers in microbiology · 2018Article
- From by-product to valuable components: Efficient enzymatic conversion of lactose in whey using β-galactosidase fromBiochemical engineering journal · 2016Article
- Comparative genome analysis of Streptococcus infantarius subsp. infantarius CJ18, an African fermented camel milk isolate with adaptations to dairy environment.BMC genomics · 2013Article
- Homodimeric β-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus DSM 20081: expression in Lactobacillus plantarum and biochemical characterization.Journal of agricultural and food chemistry · 2012Article
- Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9.Microbial cell factories · 2011Article
- Regulation of galactose metabolism through the HisK:GalR two-component system in Thermoanaerobacter tengcongensis.Journal of bacteriology · 2010Article
- A generic approach to identify Transcription Factor-specific operator motifs; Inferences for LacI-family mediated regulation in Lactobacillus plantarum WCFS1.BMC genomics · 2008Article
- Role of galK and galM in galactose metabolism by Streptococcus thermophilus.Applied and environmental microbiology · 2008Article
- Transcriptional organization and regulation of magnetosome operons in Magnetospirillum gryphiswaldense.Applied and environmental microbiology · 2006Article
- Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus salivarius is a lactose- and galactose-positive bacterium that is phylogenetically closely related to Streptococcus thermophilus, a bacterium that metabolizes lactose but not galactose. In this paper, we report a comparative characterization of the S. salivarius and S. thermophilus gal-lac gene clusters. The clusters have the same organization with the order galR (codes for a transcriptional regulator and is transcribed in the opposite direction), galK (galactokinase), galT (galactose-1-P uridylyltransferase), galE (UDP-glucose 4-epimerase), galM (galactose mutarotase), lacS (lactose transporter), and lacZ (beta-galactosidase). An analysis of the nucleotide sequence as well as Northern blotting and primer extension experiments revealed the presence of four promoters located upstream from galR, the gal operon, galM, and the lac operon of S. salivarius. Putative promoters with virtually identical nucleotide sequences were found at the same positions in the S. thermophilus gal-lac gene cluster. An additional putative internal promoter at the 3' end of galT was found in S. thermophilus but not in S. salivarius. The results clearly indicated that the gal-lac gene cluster was efficiently transcribed in both species. The Shine-Dalgarno sequences of galT and galE were identical in both species, whereas the ribosome binding site of S. thermophilus galK differed from that of S. salivarius by two nucleotides, suggesting that the S. thermophilus galK gene might be poorly translated. This was confirmed by measurements of enzyme activities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.