ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2001
Responsiveness of the EuroQol in breast cancer patients undergoing high dose chemotherapy.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Order effects: a randomised study of three major cancer-specific quality of life instruments.Health and quality of life outcomes · 2005Trial
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- Topical treatment of chemotherapy-induced peripheral neuropathy (CIPN) with high-concentration (179 mg) capsaicin patch in breast cancer patients - results of the QUCIP study.Frontiers in oncology · 2024Article
- Properties of the EQ-5D-3L index distribution when longitudinal data from 27,328 spine surgery procedures are applied to nine national EQ-5D-3L value sets.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Effect of rowing on mobility, functionality, and quality of life in women with and without breast cancer: a 4-month intervention.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- A Meta-Regression Analysis of Utility Weights for Breast Cancer: The Power of Patients' Experience.International journal of environmental research and public health · 2020Article
- [120-day follow-up after proximal femoral fractures-first results from the Geriatric Trauma Registry DGU®].Der Unfallchirurg · 2020Article
- Advances in the Functional Assessment of Patients with Sarcoma.Advances in experimental medicine and biology · 2020Review
- Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer.Cancer · 2014Article
- Health-related quality of life (EQ-5D) before and after orthopedic surgery.Acta orthopaedica · 2011Article
- Estimation and external validation of a new prognostic model for predicting recurrence-free survival for early breast cancer patients in the UK.British journal of cancer · 2010Article
- Health utilities using the EQ-5D in studies of cancer.PharmacoEconomics · 2007Review
- Measurement properties of a new quality of life measure for patients with work disability associated with musculoskeletal pain.Journal of occupational rehabilitation · 2005Article
- A longitudinal prospective study of health-related quality of life in breast cancer patients following high-dose chemotherapy with autologous blood stem cell transplantation.Bone marrow transplantation · 2005Article
- Effects of enzyme replacement therapy on pain and health related quality of life in patients with Fabry disease: data from FOS (Fabry Outcome Survey).Journal of medical genetics · 2005Article
- Validation of the English and Chinese versions of the Quick-FLIC quality of life questionnaire.British journal of cancer · 2005Article
- On assessing responsiveness of health-related quality of life instruments: guidelines for instrument evaluation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2003Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the responsiveness of the EuroQol (EQ-5D) by comparing it with the Functional Living Index-Cancer (FLIC) and a self-reported rating of health-related quality of life (HRQL).
methodsHRQL was measured four times during the course of high dose chemotherapy (HDC) and bone marrow transplantation in 40 patients with stage II and III breast cancer. Measurements were at baseline (T1), pre-HDC (T2), 3 weeks post-HDC (T3), and 3 months post-HDC (T4).
resultsEffect size ranged from 1.16 (T1-T3) to 0.66 (T3-T4) for the EQ-5D and 0.85-0.91 respectively for the FLIC. No significant differences in effect sizes between the EQ-5D and the FLIC were found. Repeated measures ANOVA yielded a significant change for all measures, with HRQL decreasing post-HDC and returning to baseline levels by 3 m post-HDC. EQ-5D dimensions changed significantly over time for mobility, self-care, and usual activities. EQ-5D index scores at T3 had a bimodal distribution. Interpretation of psychological changes was facilitated by an analysis of FLIC items.
conclusionsThe EQ-5D is responsive to the clinically large changes associated with HDC in breast cancer patients. The bimodal distribution of the EQ-5D index has implications for the interpretation of EQ-5D change scores.
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